Protein: PKHG4
Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)

Gene: PKHG4, PLEKHG4
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q58EX7

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955252

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.829

High

1201897

DOCK5
Dedicator of cytokinesis protein 5

2

2

High-throughput

0.811

High

473429

HCK
Tyrosine-protein kinase HCK

2

12

High-throughput

0.783

High

1085501

ARHG5
Rho guanine nucleotide exchange factor 5

2

12

High-throughput

0.783

High

1201842

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

2

10

High-throughput

0.783

High

914426

EFNB2
Ephrin-B2

3

1

High-throughput

0.667

High

245966

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.665

High

962124

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

845432

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

0

High-throughput

0.638

High

1201890

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

2

High-throughput

0.628

High

581089

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

953484

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

988418

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1186384

PKHG6
Pleckstrin homology domain-containing family G member 6

1

19

High-throughput

0.618

High

288429

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.606

High

341785

K2C75
Keratin, type II cytoskeletal 75

2

2

High-throughput

0.606

High

551562

K2C3
Keratin, type II cytoskeletal 3

2

2

High-throughput

0.606

High

591933

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

4

High-throughput

0.606

High

633702

PSB1
Proteasome subunit beta type-1

2

5

High-throughput

0.606

High

842969

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

5

High-throughput

0.606

High

921376

MAP11
Methionine aminopeptidase 1

2

1

High-throughput

0.606

High

1102563

MTA1
Metastasis-associated protein MTA1

2

2

High-throughput

0.606

High

1116661

RIN1
Ras and Rab interactor 1

2

4

High-throughput

0.606

High

1201863

TFG
Protein TFG

2

2

High-throughput

0.606

High

1201881

PKP2
Plakophilin-2

2

6

High-throughput

0.606

High

1201883

DCNL5
DCN1-like protein 5

2

1

High-throughput

0.606

High

1201895

SH24A
SH2 domain-containing protein 4A

2

19

High-throughput

0.606

High

1201901

TNR19
Tumor necrosis factor receptor superfamily member 19

2

0

High-throughput

0.602

High

182560

GP182
G-protein coupled receptor 182

2

5

High-throughput

0.601

High

224861

MAAI
Maleylacetoacetate isomerase

2

0

High-throughput

0.580

High

662590

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

0

High-throughput

0.580

High

892202

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.580

High

1149412

SIX1
Homeobox protein SIX1

2

0

High-throughput

0.580

High

1185247

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1201837

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.580

High

1201841

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

1201845

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1201848

MSRB3
Methionine-R-sulfoxide reductase B3

2

0

High-throughput

0.580

High

1201868

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

2

0

High-throughput

0.580

High

1201885

BEX2
Protein BEX2

2

0

High-throughput

0.580

High

1201892

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.580

High

1201900

A1CF
APOBEC1 complementation factor

2

0

High-throughput

0.580

High

1201908

DS13B
Dual specificity protein phosphatase 13B

2

0

High-throughput

0.580

High

1201910

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

0

High-throughput

0.580

High

190377

COPT1
High affinity copper uptake protein 1

2

0

High-throughput

0.576

High

1201838

PKHG7
Pleckstrin homology domain-containing family G member 7

1

15

High-throughput

0.575

High

1201846

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

6

High-throughput

0.571

High

351416

TBX18
T-box transcription factor TBX18

2

2

High-throughput

0.553

High

604826

HXB9
Homeobox protein Hox-B9

2

1

High-throughput

0.553

High

725066

HXC8
Homeobox protein Hox-C8

2

2

High-throughput

0.553

High

846332

MATR3
Matrin-3

2

1

High-throughput

0.553

High

1201835

TTC23
Tetratricopeptide repeat protein 23

2

1

High-throughput

0.553

High

1201839

SHSA6
Protein shisa-6

2

2

High-throughput

0.553

High

1201859

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.553

High

1201860

ZCH14
Zinc finger CCHC domain-containing protein 14

2

2

High-throughput

0.553

High

1201870

CC120
Coiled-coil domain-containing protein 120

2

1

High-throughput

0.553

High

1201889

SETD5
Histone-lysine N-methyltransferase SETD5

2

1

High-throughput

0.553

High

1201912

ZN148
Zinc finger protein 148

2

1

High-throughput

0.553

High

1201873

HS12B
Heat shock 70 kDa protein 12B

2

1

High-throughput

0.549

High

1201880

MDFI
MyoD family inhibitor

1

0

High-throughput

0.549

High

1201887

TRI55
Tripartite motif-containing protein 55

1

10

High-throughput

0.541

High

133257

P2Y10
Putative P2Y purinoceptor 10

1

7

High-throughput

0.536

High

212956

HS12A
Heat shock 70 kDa protein 12A

1

1

High-throughput

0.536

High

638432

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.536

High

718405

CD6
T-cell differentiation antigen CD6

1

2

High-throughput

0.536

High

956885

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

1022864

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

1201882

NAA11
N-alpha-acetyltransferase 11

1

1

High-throughput

0.536

High

1201888

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1201893

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1201909

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

1201915

NPTN
Neuroplastin

1

5

High-throughput

0.536

High

282592

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

10

High-throughput

0.515

High

415617

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

562098

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.515

High

930916

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.515

High

937021

CASP6
Caspase-6

1

2

High-throughput

0.515

High

954490

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

4

High-throughput

0.515

High

296782

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

359821

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

1201834

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1201850

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1201861

BSND
Barttin

1

0

High-throughput

0.513

High

1201864

FGF14
Fibroblast growth factor 14

1

0

High-throughput

0.513

High

1201867

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1201869

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.513

High

1201872

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

167280

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

705380

GRN
Progranulin

1

0

High-throughput

0.493

High

937636

FOXG1
Forkhead box protein G1

1

1

High-throughput

0.489

High

1091067

FOXF2
Forkhead box protein F2

1

2

High-throughput

0.489

High

1176981

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

1201875

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

1201879

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

1201865

TRI63
E3 ubiquitin-protein ligase TRIM63

1

9

High-throughput

0.481

High

123113

DX39A
ATP-dependent RNA helicase DDX39A

1

5

High-throughput

0.479

High

211335

RFOX2
RNA binding protein fox-1 homolog 2

1

7

High-throughput

0.479

High

343962

HS74L
Heat shock 70 kDa protein 4L

1

6

High-throughput

0.479

High

408079

TBB4A
Tubulin beta-4A chain

1

7

High-throughput

0.479

High

417475

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

925546

MOT1
Monocarboxylate transporter 1

1

2

High-throughput

0.479

High

973051

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.479

High

973941

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.479

High

1014902

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

1150430

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.479

High

1156372

SEPT7
Septin-7

1

1

High-throughput

0.479

High

1201862

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.479

High

1201896

AAMDC
Mth938 domain-containing protein

1

1

High-throughput

0.479

High

1201903

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.479

High

1201911

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.479

High

1201913

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

301461

WFS1
Wolframin

1

1

High-throughput

0.470

High

641303

PGS1
Biglycan

1

1

High-throughput

0.470

High

1081533

Q0VDC6
peptidylprolyl isomerase

1

1

High-throughput

0.470

High

799921

COIL
Coilin

1

1

High-throughput

0.464

High

431153

LA
Lupus La protein

1

0

High-throughput

0.458

High

1201840

BT2A1
Butyrophilin subfamily 2 member A1

1

0

High-throughput

0.458

High

1201916

TX264
Testis-expressed protein 264

1

0

High-throughput

0.458

High

754034

CD80
T-lymphocyte activation antigen CD80

1

5

High-throughput

0.445

High

1101499

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

6

High-throughput

0.445

High

1201853

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

168097

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

1

High-throughput

0.437

High

372213

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.437

High

903709

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

935888

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.437

High

1126936

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

1149081

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.437

High

1201836

RL22L
Ribosomal protein eL22-like

1

3

High-throughput

0.437

High

1201858

TM263
Transmembrane protein 263

1

4

High-throughput

0.437

High

1201866

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

6

High-throughput

0.437

High

1201876

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.437

High

1201886

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.437

High

1201891

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

7

High-throughput

0.437

High

1201898

GHC1
Mitochondrial glutamate carrier 1

1

6

High-throughput

0.437

High

1201904

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

1201905

TECR
Very-long-chain enoyl-CoA reductase

1

3

High-throughput

0.437

High

1201914

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

4

High-throughput

0.437

High

139224

UPK2
Uroplakin-2

1

0

High-throughput

0.426

High

1201877

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

1201831

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

4

High-throughput

0.407

High

1201871

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

63209

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.316

High

288304

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.316

High

733150

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.316

High

1201833

ZN648
Zinc finger protein 648

2

0

High-throughput

0.316

High

1201843

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

1201847

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1201849

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1201852

NATD1
Protein NATD1

2

0

High-throughput

0.316

High

1201854

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

1201874

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1201878

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

1201884

TEKT3
Tektin-3

2

0

High-throughput

0.316

High

1201894

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1201899

MYOZ1
Myozenin-1

2

0

High-throughput

0.316

High

1201902

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.316

High

1201906

ZN319
Zinc finger protein 319

2

0

High-throughput

0.316

High

1201907

MYEF2
Myelin expression factor 2

2

0

High-throughput

0.316

High

1201844

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

2

0

High-throughput

0.313

High

1201832

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.279

Low

1201851

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1201856

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1201857

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1201855

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

184851

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.249

Low

567877

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.249

Low

1070442

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025