Protein: ISY1
Pre-mRNA-splicing factor ISY1 homolog

Gene: ISY1
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q9ULR0

Gene Ontology (top 5):
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000389 - mRNA 3'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356966

PPIE
Peptidyl-prolyl cis-trans isomerase E

5

0

High-throughput

0.880

High

1314511

YJU2
Splicing factor YJU2

3

2

High-throughput

0.861

High

1336497

SYF1
Pre-mRNA-splicing factor SYF1

5

6

High-throughput

0.722

High

1055511

DHX8
ATP-dependent RNA helicase DHX8

4

4

High-throughput

0.705

High

1356965

PRP19
Pre-mRNA-processing factor 19

4

4

High-throughput

0.699

High

453933

RU2A
U2 small nuclear ribonucleoprotein A'

4

2

Small-scale

0.696

High

1288383

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

3

2

High-throughput

0.667

High

1310823

WDR83
WD repeat domain-containing protein 83

3

4

High-throughput

0.667

High

1251070

SNIP1
Smad nuclear-interacting protein 1

4

0

High-throughput

0.664

High

1356971

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

0

High-throughput

0.664

High

1356969

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

0

High-throughput

0.656

High

230814

AQR
RNA helicase aquarius

3

0

Small-scale

0.642

High

1309001

USB1
U6 snRNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1232030

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

3

0

High-throughput

0.636

High

209495

PLRG1
Pleiotropic regulator 1

2

2

High-throughput

0.628

High

911994

RUXF
Small nuclear ribonucleoprotein F

2

3

High-throughput

0.628

High

1298609

ZN830
Zinc finger protein 830

3

0

Small-scale

0.628

High

1159333

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.618

High

1040442

TRA2A
Transformer-2 protein homolog alpha

2

1

High-throughput

0.611

High

1054660

RBM39
RNA-binding protein 39

2

2

High-throughput

0.611

High

1197555

RALYL
RNA-binding Raly-like protein

2

4

High-throughput

0.611

High

1201753

ZCH18
Zinc finger CCCH domain-containing protein 18

2

1

High-throughput

0.611

High

1303848

CDC5L
Cell division cycle 5-like protein

2

2

High-throughput

0.611

High

638425

RBTN2
Rhombotin-2

2

2

High-throughput

0.606

High

638593

RBTN1
Rhombotin-1

2

2

High-throughput

0.606

High

883400

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

4

High-throughput

0.606

High

327822

SYF2
Pre-mRNA-splicing factor SYF2

2

0

High-throughput

0.602

High

911768

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1019686

ILF2
Interleukin enhancer-binding factor 2

2

0

High-throughput

0.602

High

1020350

ELAV2
ELAV-like protein 2

2

0

High-throughput

0.602

High

1346738

DJC17
DnaJ homolog subfamily C member 17

2

0

High-throughput

0.602

High

1356366

FBW1B
F-box/WD repeat-containing protein 11

2

0

High-throughput

0.602

High

624532

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

776426

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1286127

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.580

High

1302388

ZN587
Zinc finger protein 587

2

0

High-throughput

0.580

High

1350410

RCOR3
REST corepressor 3

2

0

High-throughput

0.580

High

1354354

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1354549

ZN629
Zinc finger protein 629

2

0

High-throughput

0.580

High

1356970

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

71276

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.536

High

236263

PRP17
Pre-mRNA-processing factor 17

1

6

High-throughput

0.536

High

241384

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

High-throughput

0.536

High

278562

SPF27
Pre-mRNA-splicing factor SPF27

1

1

High-throughput

0.536

High

432992

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.536

High

446838

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.536

High

539184

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.536

High

912753

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.536

High

928041

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

2

High-throughput

0.536

High

1039933

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1064830

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.536

High

1074262

SF3A1
Splicing factor 3A subunit 1

1

1

High-throughput

0.536

High

1103278

C19L2
CWF19-like protein 2

1

1

High-throughput

0.536

High

1148620

C19L1
CWF19-like protein 1

1

1

High-throughput

0.536

High

1260031

CCD12
Coiled-coil domain-containing protein 12

1

1

High-throughput

0.536

High

1310464

GPTC1
G patch domain-containing protein 1

1

1

High-throughput

0.536

High

1318162

CRNL1
Crooked neck-like protein 1

1

6

High-throughput

0.536

High

1332148

DHX35
Probable ATP-dependent RNA helicase DHX35

1

5

High-throughput

0.536

High

1347096

RBM22
Pre-mRNA-splicing factor RBM22

1

2

High-throughput

0.536

High

1353888

TFP11
Tuftelin-interacting protein 11

1

2

High-throughput

0.536

High

269279

WBP4
WW domain-binding protein 4

1

0

Small-scale

0.518

High

127892

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

181270

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

256595

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

304457

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

448851

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

508770

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

558545

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

595469

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

930451

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.513

High

996952

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1029157

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.513

High

1037909

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.513

High

1077168

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1084662

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1092939

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

0

High-throughput

0.513

High

1125695

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1168975

LN28B
Protein lin-28 homolog B

1

0

High-throughput

0.513

High

1173784

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

1264446

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.513

High

1288176

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.513

High

1288647

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.513

High

1329872

PININ
Pinin

1

0

High-throughput

0.513

High

1349486

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

1356968

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.513

High

1356964

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.508

High

1073185

SF3B3
Splicing factor 3B subunit 3

1

1

Small-scale

0.501

High

653768

CALR
Calreticulin

1

0

High-throughput

0.493

High

739345

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

1255612

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

1348666

WSB2
WD repeat and SOCS box-containing protein 2

1

2

High-throughput

0.489

High

1356359

PTBP2
Polypyrimidine tract-binding protein 2

1

1

High-throughput

0.481

High

245085

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

442584

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

824526

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

912130

RUXG
Small nuclear ribonucleoprotein G

1

6

High-throughput

0.479

High

1067189

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1354835

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

123086

MEN1
Menin

1

0

High-throughput

0.458

High

295391

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

313370

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

323295

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

570175

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

727437

DEK
Protein DEK

1

0

High-throughput

0.458

High

826376

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

848159

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

909316

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

918128

H4
Histone H4

1

0

High-throughput

0.458

High

1059938

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1063681

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1122737

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

1221828

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1222871

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1256473

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1314424

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1343779

ANLN
Anillin

1

0

High-throughput

0.458

High

68467

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

882636

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1146953

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1356078

DDX41
Probable ATP-dependent RNA helicase DDX41

1

0

High-throughput

0.426

High

1172913

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1273676

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.328

High

1284577

K1143
Uncharacterized protein KIAA1143

2

0

High-throughput

0.328

High

207390

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

311988

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

1135038

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

2

0

High-throughput

0.316

High

1205645

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1223281

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1236794

CC185
Coiled-coil domain-containing protein 185

2

0

High-throughput

0.316

High

1298347

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1331276

FBX44
F-box only protein 44

2

0

High-throughput

0.316

High

62178

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.279

Low

555216

CD44
CD44 antigen

1

0

High-throughput

0.279

Low

1252906

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1356967

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

740083

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.268

Low

1230137

PORIM
Porimin

1

0

High-throughput

0.268

Low

932448

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1172241

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1331610

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024