Protein: HACD
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PHS1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase PHS1) (HACD) (PTPLA homolog involved in sphingolipid biosynthesis protein 1)

Gene: HACD, PHS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 37
UniProt ID: P40857

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0000329 - fungal-type vacuole membrane
GO:0004300 - enoyl-CoA hydratase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

827075

GST1
Glutathione S-transferase 1

3

0

Small-scale

0.612

High

828533

PEX29
Peroxisomal membrane protein PEX29

2

0

High-throughput

0.565

High

641379

SEC62
Translocation protein SEC62

1

1

High-throughput

0.508

High

812911

UIP3
ULP1-interacting protein 3

1

1

High-throughput

0.508

High

812943

KTD1
Protein-toxin resistance protein KTD1

1

1

High-throughput

0.508

High

828534

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.486

High

828541

YPR71
Uncharacterized membrane protein YPR071W

1

0

High-throughput

0.486

High

828539

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

1

Small-scale

0.481

High

618876

GAP1
General amino-acid permease GAP1

1

2

Small-scale

0.479

High

797401

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

Small-scale

0.458

High

828535

HFD1
Fatty aldehyde dehydrogenase HFD1

1

1

High-throughput

0.457

High

828536

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

636321

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.438

High

764192

SPT23
Protein SPT23

1

0

High-throughput

0.438

High

828525

ERJ5
ER-localized J domain-containing protein 5

1

0

High-throughput

0.438

High

828526

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.438

High

828529

PMT3
Dolichyl-phosphate-mannose--protein mannosyltransferase 3

1

0

High-throughput

0.438

High

828530

GPC1
Glycerophosphocholine acyltransferase 1

1

0

High-throughput

0.438

High

828531

ZRG17
Protein ZRG17

1

0

High-throughput

0.438

High

828544

SRF1
Regulator of phospholipase D SRF1

1

0

High-throughput

0.438

High

828528

MPS3
Spindle pole body assembly component MPS3

2

0

High-throughput

0.300

High

828524

MEP2
Ammonium transporter MEP2

1

0

Small-scale

0.288

High

627087

RM44
Large ribosomal subunit protein mL53

1

0

High-throughput

0.238

Low

747074

SKG6
Protein SKG6

1

0

High-throughput

0.238

Low

750048

PDR3
Transcription factor PDR3

1

0

High-throughput

0.238

Low

781322

DID4
DOA4-independent degradation protein 4

1

0

High-throughput

0.238

Low

782578

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.238

Low

796418

TRM7
tRNA

1

0

High-throughput

0.238

Low

805943

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.238

Low

807051

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.238

Low

828527

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.238

Low

828532

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.238

Low

828537

PRM3
Pheromone-regulated membrane protein 3

1

0

High-throughput

0.238

Low

828538

NUR1
Nuclear rim protein 1

1

0

High-throughput

0.238

Low

828540

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.238

Low

828542

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.238

Low

828543

PAR32
Protein PAR32

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025