Protein: ACO1
Acyl-CoA desaturase 1 (EC 1.14.19.1) (Delta 9 fatty acid desaturase) (Fatty acid desaturase 1) (Stearoyl-CoA desaturase 1)

Gene: ACO1, OLE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P21147

Gene Ontology (top 5):
GO:0000001 - mitochondrion inheritance
GO:0004768 - stearoyl-CoA 9-desaturase activity
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

636269

ACO1
Acyl-CoA desaturase 1

4

0

Small-scale

0.854

High

577033

SEC63
Protein translocation protein SEC63

2

1

Small-scale

0.757

High

636304

PHO88
SRP-independent targeting protein 3

4

0

High-throughput

0.666

High

636316

CYB5
Cytochrome b5

1

5

High-throughput

0.618

High

636332

HLJ1
Protein HLJ1

1

1

High-throughput

0.618

High

528546

CP51
Lanosterol 14-alpha demethylase CYP51

1

1

High-throughput

0.541

High

636271

ELO2
Fatty acid elongase 2

1

1

High-throughput

0.541

High

636338

ERG5
C-22 sterol desaturase ERG5

1

2

High-throughput

0.541

High

636340

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.541

High

636286

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

0

High-throughput

0.518

High

636305

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.518

High

636318

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.518

High

636319

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.518

High

636331

ILM1
Protein ILM1

1

0

High-throughput

0.518

High

636311

ERP2
Protein ERP2

1

2

High-throughput

0.515

High

636326

SPC1
Signal peptidase complex subunit 1

1

1

High-throughput

0.515

High

636272

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.481

High

636292

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

1

Small-scale

0.481

High

636294

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

1

Small-scale

0.481

High

636302

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

Small-scale

0.481

High

554306

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.479

High

554396

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

636276

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

636284

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

636312

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.479

High

636315

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

Small-scale

0.479

High

636317

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.479

High

636327

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

636350

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

Small-scale

0.479

High

636354

ERP4
Protein ERP4

1

2

High-throughput

0.479

High

636352

DGAT2
Diacylglycerol O-acyltransferase 1

1

0

Small-scale

0.460

High

439503

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

636273

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

636274

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

636288

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

Small-scale

0.458

High

636293

EMP24
Endosomal protein P24B

1

0

High-throughput

0.458

High

636296

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

636301

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

636307

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

636308

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.458

High

636324

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

636325

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.458

High

636335

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.458

High

636341

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

636345

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

636347

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

636349

SEI1
Seipin

1

0

Small-scale

0.458

High

636355

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

636280

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.457

High

636334

PMT5
Dolichyl-phosphate-mannose--protein mannosyltransferase 5

1

2

High-throughput

0.457

High

636291

ANP1
Mannan polymerase II complex ANP1 subunit

1

1

High-throughput

0.445

High

636310

MNN9
Mannan polymerase complexes subunit MNN9

1

1

High-throughput

0.445

High

636321

HACD
Very-long-chain

1

0

High-throughput

0.438

High

636329

GPI14
GPI mannosyltransferase 1

1

0

High-throughput

0.438

High

523039

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.437

High

636270

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.437

High

636275

TAH1
TPR repeat-containing protein associated with Hsp90

1

1

Small-scale

0.437

High

636285

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

636295

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

636339

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

636333

MNN10
Probable alpha-1,6-mannosyltransferase MNN10

1

0

High-throughput

0.426

High

509391

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

High-throughput

0.407

High

525904

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

636290

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

392217

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.282

High

636278

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.282

High

636298

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.282

High

636300

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.282

High

599322

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.261

Low

636330

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.261

Low

636281

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

636282

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

636287

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

636289

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

636297

YKK0
Probable intramembrane protease YKL100C

1

0

High-throughput

0.249

Low

636303

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

636309

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

636320

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

636322

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

636323

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

636328

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

636336

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.249

Low

636337

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

636343

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.249

Low

636344

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

636346

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

636351

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

636353

TPO4
Polyamine transporter 4

1

0

High-throughput

0.238

Low

386563

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

403353

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.232

Low

427136

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

432486

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

435771

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.232

Low

486025

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

531601

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.232

Low

543796

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low

569714

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

592008

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

636277

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

636279

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.232

Low

636283

XPO1
Exportin-1

1

0

High-throughput

0.232

Low

636299

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

636306

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

636313

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.232

Low

636314

IMB4
Importin subunit beta-4

1

0

High-throughput

0.232

Low

636342

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low

636348

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025