Protein: SIZ2
E3 SUMO-protein ligase SIZ2 (EC 2.3.2.-) (E3 SUMO-protein transferase SIZ2) (SAP and Miz-finger domain-containing protein 2)

Gene: SIZ2, NFI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: Q12216

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007059 - chromosome segregation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897523

UBC9
SUMO-conjugating enzyme UBC9

11

14

Small-scale

0.976

High

1084619

SMT3
Ubiquitin-like protein SMT3

5

20

Small-scale

0.895

High

586496

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.647

High

1084617

SIZ2
E3 SUMO-protein ligase SIZ2

1

9

Small-scale

0.647

High

557786

SRS2
ATP-dependent DNA helicase SRS2

2

3

Small-scale

0.614

High

722359

XPO1
Exportin-1

2

2

High-throughput

0.611

High

647856

RFA1
Replication factor A protein 1

2

1

Small-scale

0.595

High

815609

RSP5
E3 ubiquitin-protein ligase RSP5

2

3

Small-scale

0.595

High

818099

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

2

1

Small-scale

0.594

High

708526

TF2B
Transcription initiation factor IIB

2

1

High-throughput

0.584

High

1043847

NSE5
Non-structural maintenance of chromosome element 5

2

1

Small-scale

0.576

High

745541

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.559

High

820118

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

850601

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.536

High

919701

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.536

High

688774

RFA2
Replication factor A protein 2

1

4

Small-scale

0.527

High

416926

CDC25
Cell division control protein 25

1

0

High-throughput

0.518

High

1084621

ARP7
Actin-related protein 7

1

3

High-throughput

0.515

High

1056358

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.513

High

1061383

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.513

High

753158

NIP80
Protein NIP100

1

2

High-throughput

0.508

High

448418

RAD1
DNA repair protein RAD1

1

2

Small-scale

0.501

High

745508

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

1

Small-scale

0.501

High

806116

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

2

Small-scale

0.501

High

814155

SAW1
Single-strand annealing weakened protein 1

1

1

Small-scale

0.501

High

814748

EXO1
Exodeoxyribonuclease 1

1

2

Small-scale

0.501

High

817321

YEN1
Holliday junction resolvase YEN1

1

2

Small-scale

0.501

High

916904

IMB5
Importin subunit beta-5

1

3

Small-scale

0.501

High

917757

XRCC4
Non-homologous end-joining factor LIF1

1

1

Small-scale

0.501

High

1064293

SGO1
Shugoshin

1

1

High-throughput

0.501

High

806018

LIN1
Protein LIN1

1

0

Small-scale

0.486

High

809168

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.486

High

737061

CDC3
Cell division control protein 3

1

1

Small-scale

0.481

High

486353

TBA1
Tubulin alpha-1 chain

1

1

Small-scale

0.481

High

486531

TBA3
Tubulin alpha-3 chain

1

1

Small-scale

0.481

High

738514

NUP2
Nucleoporin NUP2

1

3

Small-scale

0.481

High

815670

LIS1
Nuclear distribution protein PAC1

1

2

Small-scale

0.481

High

824885

NDC80
Kinetochore protein NDC80

1

3

High-throughput

0.481

High

1038121

ULP1
Ubiquitin-like-specific protease 1

1

2

Small-scale

0.481

High

1044172

GIS1
Transcriptional activator/repressor GIS1

1

2

Small-scale

0.481

High

1046698

EUC1
Transcription factor-like protein EUC1

1

1

Small-scale

0.481

High

1084195

ELG1
Telomere length regulation protein ELG1

1

5

Small-scale

0.481

High

449028

TOP2
DNA topoisomerase 2

1

4

High-throughput

0.479

High

557649

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.479

High

584399

GCN2
eIF-2-alpha kinase GCN2

1

1

High-throughput

0.479

High

594637

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

632834

DBP5
ATP-dependent RNA helicase DBP5

1

4

High-throughput

0.479

High

670359

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.479

High

679013

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.479

High

734495

BTAF1
TATA-binding protein-associated factor MOT1

1

6

High-throughput

0.479

High

739818

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

780481

NNRD
ATP-dependent

1

1

High-throughput

0.479

High

800985

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.479

High

801032

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

813575

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.479

High

843208

EMW1
Essential for maintenance of the cell wall protein 1

1

5

High-throughput

0.479

High

850260

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

865658

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.479

High

917076

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

917335

INO80
Chromatin-remodeling ATPase INO80

1

5

High-throughput

0.479

High

1026978

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

1

High-throughput

0.479

High

1055689

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

8

High-throughput

0.479

High

1056531

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

1

High-throughput

0.479

High

1060047

ADY3
Accumulates dyads protein 3

1

5

High-throughput

0.479

High

1084117

MDN1
Midasin

1

6

High-throughput

0.479

High

1084620

ARP8
Actin-like protein ARP8

1

3

High-throughput

0.479

High

1084622

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

1084623

YB11B
Transposon Ty1-BL Gag-Pol polyprotein

1

1

High-throughput

0.479

High

737126

CDC11
Cell division control protein 11

1

3

High-throughput

0.464

High

864761

BBC1
Myosin tail region-interacting protein MTI1

1

4

High-throughput

0.464

High

386914

TBB
Tubulin beta chain

1

0

Small-scale

0.460

High

700165

PRP45
Pre-mRNA-processing protein 45

1

0

Small-scale

0.460

High

734282

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.460

High

738785

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

Small-scale

0.460

High

739315

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

780993

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

1045027

ECM11
Protein ECM11

1

0

Small-scale

0.460

High

1046726

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

1084618

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

1084624

HUB1
Ubiquitin-like modifier HUB1

1

0

Small-scale

0.460

High

358427

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.458

High

367508

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.458

High

402150

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

464348

OAT
Ornithine aminotransferase

1

0

High-throughput

0.458

High

470612

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

550705

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.458

High

624952

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

632382

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

701663

OPLA
5-oxoprolinase

1

0

High-throughput

0.458

High

738443

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

782562

NU133
Nucleoporin NUP133

1

0

High-throughput

0.458

High

795275

NU170
Nucleoporin NUP170

1

0

Small-scale

0.458

High

797930

SDS24
Protein SDS24

1

0

High-throughput

0.458

High

805273

SBE22
Protein SBE22

1

0

High-throughput

0.458

High

806959

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.458

High

816936

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.458

High

845903

UAP1
UDP-N-acetylglucosamine pyrophosphorylase

1

0

High-throughput

0.458

High

868462

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

924467

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

1041930

YM44
Uncharacterized protein YMR178W

1

0

High-throughput

0.458

High

1043365

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

1044328

DOP1
Protein DOP1

1

0

High-throughput

0.458

High

1044979

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

1046961

POB3
FACT complex subunit POB3

1

0

High-throughput

0.458

High

1047513

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

1049107

YM94
Uncharacterized protein YMR315W

1

0

High-throughput

0.458

High

1083824

LKHA4
Leucine aminopeptidase 2

1

0

High-throughput

0.458

High

548248

BIK1
Nuclear fusion protein BIK1

1

1

Small-scale

0.439

High

805024

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.438

High

924777

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

454244

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.437

High

480009

PRTB
Cerevisin

1

1

High-throughput

0.437

High

554743

YPK1
Serine/threonine-protein kinase YPK1

1

4

High-throughput

0.437

High

616463

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.437

High

673341

TRX3
Thioredoxin-3, mitochondrial

1

4

High-throughput

0.437

High

850359

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

1

High-throughput

0.437

High

850760

COPD
Coatomer subunit delta

1

1

High-throughput

0.437

High

918153

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

1043573

ESC1
Silent chromatin protein ESC1

1

1

Small-scale

0.437

High

1044894

YHM2
Citrate/oxoglutarate carrier protein

1

1

High-throughput

0.437

High

580246

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.426

High

824675

BNR1
BNI1-related protein 1

1

1

High-throughput

0.417

High

780347

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.288

High

816982

BIM1
Protein BIM1

1

0

Small-scale

0.251

Low

858405

STU2
Protein STU2

1

0

Small-scale

0.251

Low

438504

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.249

Low

482106

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.249

Low

569425

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.249

Low

604445

KHSE
Homoserine kinase

1

0

High-throughput

0.249

Low

673278

GFD2
Good for full DBP5 activity protein 2

1

0

High-throughput

0.249

Low

715051

ERG9
Squalene synthase ERG9

1

0

High-throughput

0.249

Low

732895

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

743729

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

779455

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

793638

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

801123

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

818211

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

Small-scale

0.249

Low

849567

GCN20
Protein GCN20

1

0

High-throughput

0.249

Low

1052975

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.249

Low

828540

HACD
Very-long-chain

1

0

High-throughput

0.238

Low

865240

GPI14
GPI mannosyltransferase 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025