Protein: NPC1
NPC intracellular sterol transporter 1-related protein 1 (Niemann-Pick type C-related protein 1)

Gene: NPC1, NCR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: Q12200

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0005783 - endoplasmic reticulum
GO:0006665 - sphingolipid metabolic process
GO:0015918 - sterol transport
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084599

NPC2
Phosphatidylglycerol/phosphatidylinositol transfer protein

2

0

Small-scale

0.738

High

822195

CYB5
Cytochrome b5

1

2

Small-scale

0.552

High

807753

ATC2
Calcium-transporting ATPase 2

1

5

High-throughput

0.541

High

751142

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

High-throughput

0.532

High

763169

SC61G
Protein transport protein SSS1

1

0

Small-scale

0.529

High

1043424

LIP1
Ceramide synthase subunit LIP1

1

0

Small-scale

0.529

High

740381

SNQ2
Protein SNQ2

1

2

High-throughput

0.494

High

577244

SEC63
Protein translocation protein SEC63

1

7

Small-scale

0.481

High

748585

SC61A
Protein transport protein SEC61

1

2

Small-scale

0.481

High

798676

SSH1
Sec sixty-one protein homolog

1

2

Small-scale

0.481

High

802502

LAG1
Ceramide synthase LAG1

1

3

Small-scale

0.481

High

828539

HACD
Very-long-chain

1

1

Small-scale

0.481

High

835072

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

Small-scale

0.481

High

914907

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.481

High

914917

SC6B2
Protein transport protein SBH2

1

1

Small-scale

0.481

High

1084600

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

3

Small-scale

0.481

High

547078

PPB
Repressible alkaline phosphatase

1

1

High-throughput

0.479

High

673316

ADP1
Probable ATP-dependent permease

1

3

High-throughput

0.479

High

735768

VA0D
V-type proton ATPase subunit d

1

1

High-throughput

0.479

High

740105

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

4

High-throughput

0.479

High

849981

VTC2
Vacuolar transporter chaperone complex subunit 2

1

4

High-throughput

0.479

High

864909

VTC4
Vacuolar transporter chaperone complex subunit 4

1

4

High-throughput

0.479

High

877936

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

1038142

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

4

High-throughput

0.479

High

798754

YSY6
Protein YSY6

1

0

Small-scale

0.460

High

693208

PHO91
Low-affinity phosphate transporter PHO91

1

0

High-throughput

0.458

High

736210

YBT1
ATP-dependent bile acid permease

1

0

High-throughput

0.458

High

743728

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

808361

VTC5
Vacuole transporter chaperone complex subunit 5

1

0

High-throughput

0.458

High

745058

YSC84
Protein YSC84

1

1

High-throughput

0.457

High

850504

LSB3
LAS seventeen-binding protein 3

1

1

High-throughput

0.457

High

1084509

PSH1
RING finger protein PSH1

1

1

Small-scale

0.439

High

708521

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

546728

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.407

High

742982

HSP79
Heat shock protein homolog SSE2

1

6

High-throughput

0.407

High

820112

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.407

High

1084173

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.282

High

917954

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

445379

CDC31
Cell division control protein 31

1

0

High-throughput

0.249

Low

779890

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.249

Low

677295

PEX34
Peroxisomal membrane protein PEX34

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025