HitPredict

Interactor 1: IRF3 (P70671)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: ISG15 (Q64339)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein)
Gene: ISG15

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17468758
Identification Methods	electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0009617 - response to bacterium GO:0032728 - positive regulation of interferon-beta production GO:0051607 - defense response to virus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 419 Mm			1 161
+	Hs
		507192 IRF3_HUMAN (1-417): 0: 524: 71.06		UBB_HUMAN (2-155): 1.37e-64: 198: 33.12
+	Hs
		425502 IRF3_HUMAN (1-417): 0: 524: 71.06		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Mm
		660993 IRF8_MOUSE (7-380): 8.12e-139: 405: 26.45		ISG15_MOUSE (1-161): 3.29e-49: 157: 100.00
+	Mm
		508994 IRF5_MOUSE (2-414): 1.28e-146: 427: 27.04		UBC_MOUSE (2-108): 2.31e-32: 123: 29.91
+	Hs
		425515 IRF4_HUMAN (7-391): 3.77e-148: 429: 27.64		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425453 IRF8_HUMAN (7-380): 2.34e-138: 404: 26.82		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425594 IRF7_HUMAN (4-376): 1.84e-121: 363: 25.60		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425450 IRF9_HUMAN (7-383): 4.45e-120: 356: 24.50		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425275 IRF1_HUMAN (1-200): 1.57e-65: 214: 27.67		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425288 IRF2_HUMAN (1-116): 3.18e-48: 169: 33.90		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25