Protein: IRF9
Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)

Gene: IRF9
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q00978

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002376 - immune system process
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

913126

STAT2
Signal transducer and activator of transcription 2

15

20

Small-scale

0.984

High

838058

STAT1
Signal transducer and activator of transcription 1-alpha/beta

6

20

Small-scale

0.936

High

533916

IRF1
Interferon regulatory factor 1

3

15

Small-scale

0.849

High

1028123

IRF9
Interferon regulatory factor 9

2

16

Small-scale

0.754

High

1028136

IRF7
Interferon regulatory factor 7

2

16

Small-scale

0.754

High

369175

OAS1
2'-5'-oligoadenylate synthase 1

3

2

Small-scale

0.640

High

274134

ANR17
Ankyrin repeat domain-containing protein 17

2

3

High-throughput

0.628

High

1028129

UB2R2
Ubiquitin-conjugating enzyme E2 R2

2

2

High-throughput

0.628

High

1028132

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

3

High-throughput

0.628

High

1028145

ARI1
E3 ubiquitin-protein ligase ARIH1

2

5

High-throughput

0.628

High

873907

INAR2
Interferon alpha/beta receptor 2

2

1

Small-scale

0.628

High

827744

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.618

High

838226

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.618

High

1028127

IRF5
Interferon regulatory factor 5

1

17

Small-scale

0.618

High

1028135

CBP
CREB-binding protein

1

17

Small-scale

0.618

High

1028141

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

High-throughput

0.602

High

425450

ISG15
Ubiquitin-like protein ISG15

2

10

Small-scale

0.584

High

488049

IFI6
Interferon alpha-inducible protein 6

2

1

Small-scale

0.584

High

123911

MYO1F
Unconventional myosin-If

1

3

High-throughput

0.541

High

224977

TLX3
T-cell leukemia homeobox protein 3

1

6

High-throughput

0.541

High

226535

TLX2
T-cell leukemia homeobox protein 2

1

8

High-throughput

0.541

High

330120

VENTX
Homeobox protein VENTX

1

4

High-throughput

0.541

High

576217

PO2F1
POU domain, class 2, transcription factor 1

1

4

High-throughput

0.541

High

725133

HXC9
Homeobox protein Hox-C9

1

8

High-throughput

0.541

High

1028131

ARI3B
AT-rich interactive domain-containing protein 3B

1

7

High-throughput

0.541

High

1028146

NR2E3
Photoreceptor-specific nuclear receptor

1

2

High-throughput

0.541

High

1028126

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.536

High

1028143

MTUS1
Microtubule-associated tumor suppressor 1

1

2

High-throughput

0.536

High

1028144

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.536

High

1028147

HCFC2
Host cell factor 2

1

4

High-throughput

0.536

High

1028133

DMRTD
Doublesex- and mab-3-related transcription factor C2

1

0

High-throughput

0.518

High

1028137

DACH2
Dachshund homolog 2

1

0

High-throughput

0.518

High

1028138

S10AD
Protein S100-A13

1

0

High-throughput

0.518

High

1028140

GLP3L
Golgi phosphoprotein 3-like

1

0

High-throughput

0.513

High

626181

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.501

High

1028125

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

1028130

I2BP1
Interferon regulatory factor 2-binding protein 1

1

3

Small-scale

0.481

High

390394

CXL10
C-X-C motif chemokine 10

1

10

Small-scale

0.479

High

413637

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

488114

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

8

Small-scale

0.479

High

488170

IFIT1
Antiviral innate immune response effector IFIT1

1

8

Small-scale

0.479

High

560364

IFM1
Interferon-induced transmembrane protein 1

1

1

Small-scale

0.479

High

736884

GBP1
Guanylate-binding protein 1

1

9

Small-scale

0.479

High

1028124

IFM3
Interferon-induced transmembrane protein 3

1

1

Small-scale

0.479

High

1028128

PWP1
Periodic tryptophan protein 1 homolog

1

1

High-throughput

0.479

High

1028134

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

2

Small-scale

0.479

High

1028142

EVL
Ena/VASP-like protein

1

1

Small-scale

0.479

High

1028148

DNM3A
DNA

1

0

Small-scale

0.458

High

712723

IL12A
Interleukin-12 subunit alpha

1

7

Small-scale

0.437

High

1028139

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.437

High

388179

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

541954

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.408

High

96876

E9PDP5
Ankyrin repeat and KH domain containing 1

1

3

High-throughput

0.407

High

654489

FBLN1
Fibulin-1

2

0

High-throughput

0.328

High

166899

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025