HitPredict

Interactor 1: PROF (P07274)
Profilin
Gene: PFY1

Interactor 2: BNI1 (P41832)
Protein BNI1 (Pointed projection formation protein 3) (Sensitive to high expression protein 5) (Synthetic lethal 39)
Gene: BNI1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	9184220, 11489916, 9082982, 22247555
Identification Methods	filter binding, biochemical, two hybrid, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:1903475 - mitotic actomyosin contractile ring assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Sc			1 1953
+	Hs
		430404 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		FHOD1_HUMAN (966-1921): 2.09e-103: 363: 14.13
+	Hs
		715022 PROF2_HUMAN (3-126): 4.02e-34: 117: 23.74		FHOD1_HUMAN (966-1921): 2.09e-103: 363: 14.13
+	Sc
		425514 PROF_YEAST (1-126): 9.67e-51: 158: 100.00		BNR1_YEAST (1316-1848): 2.35e-86: 314: 29.46
+	Hs
		430356 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		FMN2_HUMAN (1319-1782): 4.86e-89: 325: 16.94
+	Sp
		764559 PROF_SCHPO (1-126): 3.51e-49: 154: 52.76		CDC12_SCHPO (37-958): 1.06e-80: 298: 15.01
+	At
		221287 PRF3_ARATH (1-125): 7.62e-54: 168: 29.77		FH4_ARATH (1238-1764): 2.98e-79: 281: 16.98
+	Ce
		109520 PROF1_CAEEL (1-126): 1.09e-37: 125: 26.52		H2KYI3_CAEEL (1290-1907): 2.03e-87: 318: 15.52
+	At
		221286 PRF2_ARATH (1-125): 1.06e-50: 158: 30.53		FH4_ARATH (1238-1764): 2.98e-79: 281: 16.98
+	Hs
		430307 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		FMNL2_HUMAN (158-716): 5.71e-69: 256: 12.79
+	Hs
		314830 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		FMNL1_HUMAN (180-673): 5.5e-65: 244: 13.69
+	Hs
		237549 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		DIAP1_HUMAN (222-805): 3.01e-63: 240: 13.61
+	Hs
		430352 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		DIAP3_HUMAN (219-765): 1.59e-61: 234: 12.39
+	Hs
		314847 PROF2_HUMAN (3-126): 4.02e-34: 117: 23.74		FMNL1_HUMAN (180-673): 5.5e-65: 244: 13.69
+	Hs
		237564 PROF2_HUMAN (3-126): 4.02e-34: 117: 23.74		DIAP1_HUMAN (222-805): 3.01e-63: 240: 13.61
+	Dm
		639194 PROF_DROME (1-126): 4.63e-50: 157: 39.37		Q8IRY0_DROME (247-830): 1.82e-48: 192: 11.88
+	Dm
		639180 PROF_DROME (1-126): 4.63e-50: 157: 39.37		DIA_DROME (238-752): 3.15e-48: 191: 12.24
+	Hs
		243087 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		DIAP2_HUMAN (220-764): 9.27e-55: 212: 13.95
+	Dd
		640684 PROF2_DICDI (1-123): 1.18e-41: 135: 39.02		FORH_DICDI (249-803): 1.79e-27: 124: 13.84
+	Hs
		430197 PROF1_HUMAN (3-126): 1.91e-38: 128: 25.18		INF2_HUMAN (349-686): 3.46e-17: 90.5: 12.43
+	Hs
		714970 PROF2_HUMAN (3-126): 4.02e-34: 117: 23.74		INF2_HUMAN (349-686): 3.46e-17: 90.5: 12.43