HitPredict

Interactor 1: IRF8 (P23611)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
Gene: IRF8

Interactor 2: ISG15 (Q64339)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein)
Gene: ISG15

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10981959
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0009617 - response to bacterium GO:0032729 - positive regulation of type II interferon production GO:0042742 - defense response to bacterium
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 424 Mm			1 161
+	Hs
		425453 IRF8_HUMAN (1-424): 0: 574: 89.67		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		507192 IRF3_HUMAN (9-388): 6.98e-146: 423: 28.72		UBB_HUMAN (2-155): 1.37e-64: 198: 33.12
+	Mm
		508994 IRF5_MOUSE (9-422): 1.82e-165: 476: 33.04		UBC_MOUSE (2-108): 2.31e-32: 123: 29.91
+	Mm
		1000528 IRF3_MOUSE (9-396): 7.47e-136: 397: 24.69		ISG15_MOUSE (1-161): 3.29e-49: 157: 100.00
+	Hs
		425515 IRF4_HUMAN (6-384): 4.66e-155: 447: 42.27		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425502 IRF3_HUMAN (9-388): 6.98e-146: 423: 28.72		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425450 IRF9_HUMAN (5-385): 1.14e-130: 383: 34.01		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425594 IRF7_HUMAN (12-383): 4.87e-111: 337: 21.46		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425275 IRF1_HUMAN (9-266): 9.36e-86: 266: 27.27		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25
+	Hs
		425288 IRF2_HUMAN (9-167): 5.96e-59: 197: 37.50		ISG15_HUMAN (3-82): 2.97e-09: 54.9: 26.25