HitPredict

Interactor 1: RPN1 (P87048)
26S proteasome regulatory subunit rpn1 (19S regulatory cap region of 26S protease subunit 2) (Proteasome non-ATPase subunit mts4)
Gene: RPN1

Interactor 2: PSA4 (Q10329)
Probable proteasome subunit alpha type-4
Gene: pre6

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20133687, 28784663
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0034399 - nuclear periphery GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 891 Sp			1 259
+	Hs
		165320 PSMD2_HUMAN (1-885): 0: 1224: 47.36		PSA7_HUMAN (4-230): 1.02e-97: 287: 54.59
+	Sp
		1017853 RPN1_SCHPO (1-891): 0: 1228: 100.00		PSA5_SCHPO (2-235): 8.78e-95: 280: 33.06
+	Hs
		700622 PSMD2_HUMAN (1-885): 0: 1224: 47.36		PSA5_HUMAN (2-232): 1.59e-94: 279: 34.03
+	Hs
		680862 PSMD2_HUMAN (1-885): 0: 1224: 47.36		PSA1_HUMAN (2-259): 8.42e-93: 275: 27.27
+	Sp
		1017837 RPN1_SCHPO (1-891): 0: 1228: 100.00		PSA3_SCHPO (1-238): 9.14e-91: 270: 32.26
+	Hs
		954802 PSMD2_HUMAN (1-885): 0: 1224: 47.36		PSA6_HUMAN (2-236): 9.64e-91: 270: 29.88
+	Sp
		314461 RPN1_SCHPO (1-891): 0: 1228: 100.00		PSA2_SCHPO (4-211): 2.05e-44: 151: 37.44
+	Hs
		681155 PSMD2_HUMAN (1-885): 0: 1224: 47.36		PSA2_HUMAN (3-210): 2.48e-45: 153: 38.10
+	Dm
		1376944 Q9VW54_DROME (41-885): 0: 1064: 46.89		PSA5_DROME (2-233): 1.61e-94: 279: 34.44
+	Dm
		652807 Q9VW54_DROME (41-885): 0: 1064: 46.89		PSA71_DROME (2-229): 6.3e-92: 273: 52.61
+	Dm
		821939 Q9VW54_DROME (41-885): 0: 1064: 46.89		PSA2_DROME (4-212): 3.07e-48: 161: 37.92
+	Sc
		803568 RPN1_YEAST (50-885): 0: 901: 39.42		PSA4_YEAST (1-232): 9.75e-94: 277: 58.48
+	Hs
		165399 PSMD1_HUMAN (141-826): 6.12e-171: 522: 19.43		PSA7_HUMAN (4-230): 1.02e-97: 287: 54.59
+	Hs
		700715 PSMD1_HUMAN (141-826): 6.12e-171: 522: 19.43		PSA5_HUMAN (2-232): 1.59e-94: 279: 34.03
+	Hs
		680999 PSMD1_HUMAN (141-826): 6.12e-171: 522: 19.43		PSA1_HUMAN (2-259): 8.42e-93: 275: 27.27
+	Hs
		954888 PSMD1_HUMAN (141-826): 6.12e-171: 522: 19.43		PSA6_HUMAN (2-236): 9.64e-91: 270: 29.88
+	Sc
		740171 RPN2_YEAST (60-822): 4.17e-145: 455: 18.37		PSA4_YEAST (1-232): 9.75e-94: 277: 58.48
+	Dm
		652765 PSMD1_DROME (370-819): 2.86e-141: 447: 21.91		PSA71_DROME (2-229): 6.3e-92: 273: 52.61
+	Hs
		681219 PSMD1_HUMAN (141-826): 6.12e-171: 522: 19.43		PSA2_HUMAN (3-210): 2.48e-45: 153: 38.10
+	Dm
		821879 PSMD1_DROME (370-819): 2.86e-141: 447: 21.91		PSA2_DROME (4-212): 3.07e-48: 161: 37.92