HitPredict

Interactor 1: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 28514442, 29997244, 26264872, 32203420, 33961781, 35271311, 16407834, 16628223, 31980649, 11157752, 20936779, 23455922, 17392278, unassigned2213, 16101281, unassigned2173, 32814053, 16492808
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, protein kinase assay, anti tag coimmunoprecipitation, nuclear magnetic resonance, classical fluorescence spectroscopy, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, two hybrid pooling approach and 2 others

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Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase
Common GO terms GO:0001726 - ruffle
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005925 - focal adhesion
and 4 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 545
Hs

1 803
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024