HitPredict

Interactor 1: SRSF9 (Q13242)
Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)
Gene: SRSF9

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006397 - mRNA processing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 551
+	Hs
		992791 SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1028937 SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Mm
		1112117 SRSF6_MOUSE (15-176): 1.27e-50: 169: 36.67		CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62
+	Hs
		1084591 RBM4B_HUMAN (5-102): 8.16e-18: 82.6: 20.41		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		992845 SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1073600 SF3B4_HUMAN (1-211): 2.82e-49: 167: 15.32		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		993771 SRSF4_HUMAN (15-169): 2.97e-47: 164: 39.52		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516478 SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516493 SRSF9_HUMAN (1-221): 1.6e-55: 178: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516495 PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516339 PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516689 PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Hs
		992912 SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		297862 SF3B4_HUMAN (1-211): 2.82e-49: 167: 15.32		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Hs
		1029082 SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Sc
		376899 NOP3_YEAST (7-179): 6.54e-38: 137: 27.68		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Zm
		8143 A0A1D6ELH4_MAIZE (12-218): 6.46e-20: 89.5: 14.68		A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55
+	Hs
		1308748 RBM4B_HUMAN (5-102): 8.16e-18: 82.6: 20.41		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59