HitPredict

Interactor 1: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Interactor 2: ZN274 (Q96GC6)
Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)
Gene: ZNF274

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	25421577, 33961781, 21170338, 28514442, 19850934, 31403225
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Hs			1 653
+	Hs
		728566 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF93_HUMAN (198-652): 3.52e-175: 514: 23.52
+	Hs
		67425 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN850_HUMAN (55-613): 1.39e-165: 504: 15.82
+	Hs
		264762 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN254_HUMAN (70-588): 1.49e-165: 490: 14.42
+	Hs
		64141 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN729_HUMAN (55-600): 8.73e-152: 472: 15.27
+	Hs
		258851 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		Z780A_HUMAN (332-652): 5.49e-127: 391: 27.10
+	Hs
		477790 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN888_HUMAN (55-449): 6.72e-90: 296: 6.67
+	Hs
		67864 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN724_HUMAN (61-424): 4.76e-86: 283: 6.30
+	Hs
		64159 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN726_HUMAN (284-653): 6.1e-83: 275: 29.46
+	Hs
		563251 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF12_HUMAN (65-420): 5.97e-81: 272: 5.32
+	Hs
		565091 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF7_HUMAN (74-587): 8.8e-80: 268: 13.92
+	Hs
		563805 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF30_HUMAN (55-422): 4.64e-78: 262: 5.56
+	Hs
		152711 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN197_HUMAN (97-337): 1.43e-43: 170: 6.20
+	Hs
		73013 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		B4DU56_HUMAN (64-338): 2.34e-44: 169: 4.71
+	Hs
		563368 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF19_HUMAN (459-637): 6.76e-41: 157: 43.58
+	Hs
		161823 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN263_HUMAN (322-531): 1.2e-32: 135: 18.86
+	Hs
		563268 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN708_HUMAN (11-122): 1.29e-25: 113: 32.14
+	Hs
		599069 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF10_HUMAN (1-86): 1.16e-18: 92: 55.81
+	Hs
		565117 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZNF8_HUMAN (6-104): 9.28e-16: 82.8: 47.06
+	Hs
		299537 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ZN432_HUMAN (598-653): 1.33e-11: 69.6: 37.50
+	Hs
		240840 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		Z354A_HUMAN (552-653): 7.55e-09: 60.9: 25.49