HitPredict

Interactor 1: EIF3I (Q13347)
Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)
Gene: EIF3I

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29395067, 24981860
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~DEAD
Common GO terms	GO:0002183 - cytoplasmic translational initiation GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0006413 - translational initiation
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 407
+	Hs
		892792 EIF3I_HUMAN (1-325): 3.67e-93: 281: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		134019 EIF3I_HUMAN (1-325): 3.67e-93: 281: 100.00		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		181721 POC1A_HUMAN (81-324): 1.17e-56: 190: 14.63		DDX3Y_HUMAN (2-406): 3.31e-128: 385: 29.98
+	Hs
		903410 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		571382 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		133956 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		757532 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Hs
		892870 FBXW7_HUMAN (5-75): 4.23e-09: 59.6: 24.05		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		1271621 SNR40_HUMAN (3-122): 1.87e-26: 108: 20.93		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		571547 SNR40_HUMAN (3-122): 1.87e-26: 108: 20.93		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		757710 SNR40_HUMAN (3-122): 1.87e-26: 108: 20.93		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Hs
		1271615 FBXW7_HUMAN (5-75): 4.23e-09: 59.6: 24.05		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		134154 FBXW7_HUMAN (5-75): 4.23e-09: 59.6: 24.05		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		134258 STRAP_HUMAN (186-316): 4.07e-09: 58.9: 20.15		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51