HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: IKZF5 (Q9H5V7)
Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)
Gene: IKZF5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.719

Property	Details
Experiments	30217970, 27107012, 10978333, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0019904 - protein domain specific binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 419
+	Hs
		1033630 IKZF1_HUMAN (1-519): 0: 664: 100.00		IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19
+	Hs
		1033756 IKZF1_HUMAN (1-519): 0: 664: 100.00		IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22
+	Hs
		1033755 IKZF1_HUMAN (1-519): 0: 664: 100.00		IKZF2_HUMAN (10-419): 1.11e-99: 308: 23.19
+	Hs
		1332094 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		IKZF5_HUMAN (1-419): 0: 536: 100.00
+	Hs
		1329653 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		IKZF5_HUMAN (1-419): 0: 536: 100.00
+	Hs
		1332095 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		IKZF5_HUMAN (1-419): 0: 536: 100.00
+	Hs
		1033731 IKZF1_HUMAN (1-519): 0: 664: 100.00		IKZF4_HUMAN (14-417): 3.41e-80: 259: 21.54
+	Hs
		1356563 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22
+	Hs
		1329658 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22
+	Hs
		1356562 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		IKZF2_HUMAN (10-419): 1.11e-99: 308: 23.19
+	Hs
		152714 ZN197_HUMAN (2-458): 3.57e-172: 514: 14.35		ZN397_HUMAN (39-216): 1.15e-66: 223: 20.79
+	Hs
		152707 ZN197_HUMAN (2-458): 3.57e-172: 514: 14.35		ZSC20_HUMAN (24-216): 6.34e-61: 214: 17.89
+	Hs
		1239558 ZFP62_HUMAN (30-518): 1.6e-165: 493: 14.84		ZNF71_HUMAN (2-192): 8.02e-66: 219: 21.61
+	Hs
		1329652 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		IKZF4_HUMAN (14-417): 3.41e-80: 259: 21.54
+	Hs
		983758 ZNF91_HUMAN (33-518): 6.36e-161: 489: 14.93		ZKSC8_HUMAN (77-220): 4.89e-54: 190: 22.54