HitPredict

Interactor 1: ID2 (Q02363)
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
Gene: ID2

Interactor 2: HTF4 (Q99081)
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: TCF12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	26735018, 9242638, 28514442, 33961781, 35440621, 19321746, 16549780, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 134 Hs			1 682
+	Mm
		832351 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Hs
		832326 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Hs
		1037115 ID3_HUMAN (1-133): 8.42e-44: 141: 39.13		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Mm
		1222614 Q6GTZ3_MOUSE (15-133): 8.48e-45: 144: 46.83		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Mm
		832350 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Hs
		587053 ID2_HUMAN (1-134): 1.83e-70: 209: 100.00		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		587448 ID2_HUMAN (1-134): 1.83e-70: 209: 100.00		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Mm
		1221382 Q6GTZ3_MOUSE (15-133): 8.48e-45: 144: 46.83		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Mm
		586085 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Hs
		587019 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		587054 ID3_HUMAN (1-133): 8.42e-44: 141: 39.13		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		587424 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		587449 ID3_HUMAN (1-133): 8.42e-44: 141: 39.13		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Rn
		639856 ID3_RAT (1-133): 5.74e-42: 136: 38.41		TFE2_RAT (1-682): 0: 752: 49.14
+	Mm
		586119 Q6GTZ3_MOUSE (15-133): 8.48e-45: 144: 46.83		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		586079 ID1_MOUSE (15-123): 2.98e-41: 136: 50.00		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		586084 ID3_MOUSE (1-133): 1.21e-41: 135: 38.41		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		832353 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		Q91XK1_MOUSE (193-682): 0: 601: 65.41
+	Mm
		627916 ID1_MOUSE (15-123): 2.98e-41: 136: 50.00		Q91XK1_MOUSE (193-682): 0: 601: 65.41
+	Hs
		117291 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		K7EMM4_HUMAN (455-682): 1.05e-97: 301: 52.16