Protein: ID3
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)

Gene: ID3
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q02535

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001656 - metanephros development
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587054

ITF2
Transcription factor 4

9

20

Small-scale

0.978

High

587449

TFE2
Transcription factor E2-alpha

9

20

Small-scale

0.974

High

1037115

HTF4
Transcription factor 12

8

20

Small-scale

0.966

High

1037099

FHL2
Four and a half LIM domains protein 2

3

3

Small-scale

0.853

High

65878

MSGN1
Mesogenin-1

2

16

High-throughput

0.783

High

561210

MYF5
Myogenic factor 5

2

17

High-throughput

0.783

High

885218

HXA1
Homeobox protein Hox-A1

2

2

High-throughput

0.783

High

965435

LMO4
LIM domain transcription factor LMO4

2

4

High-throughput

0.783

High

1037095

ID3
DNA-binding protein inhibitor ID-3

1

4

Small-scale

0.656

High

1037120

MLX
Max-like protein X

1

3

Small-scale

0.656

High

787860

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.647

High

1037113

PDLI5
PDZ and LIM domain protein 5

1

2

Small-scale

0.647

High

558976

LYL1
Protein lyl-1

1

20

High-throughput

0.618

High

581644

MYOD1
Myoblast determination protein 1

1

13

Small-scale

0.618

High

916084

NKX25
Homeobox protein Nkx-2.5

1

2

Small-scale

0.618

High

220235

FRS3
Fibroblast growth factor receptor substrate 3

2

1

High-throughput

0.606

High

1037112

KAT5
Histone acetyltransferase KAT5

2

1

High-throughput

0.606

High

140233

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

1037097

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.580

High

851526

GATA4
Transcription factor GATA-4

1

2

Small-scale

0.561

High

1037119

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

Small-scale

0.561

High

1037106

CV039
Synaptic plasticity regulator PANTS

2

1

High-throughput

0.553

High

216171

MTG8R
Protein CBFA2T2

1

5

High-throughput

0.541

High

1037102

E2F4
Transcription factor E2F4

1

1

High-throughput

0.541

High

1037116

PRD14
PR domain zinc finger protein 14

1

2

High-throughput

0.541

High

1037122

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.541

High

282238

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.518

High

1037103

Q49AR9
ANKS1A protein

1

1

High-throughput

0.515

High

1037108

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

600492

ZNF3
Zinc finger protein 3

1

1

Small-scale

0.508

High

617151

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

1

Small-scale

0.508

High

834175

CSK
Tyrosine-protein kinase CSK

1

1

Small-scale

0.508

High

1037118

ZN408
Zinc finger protein 408

1

1

Small-scale

0.508

High

667792

CDK2
Cyclin-dependent kinase 2

1

4

Small-scale

0.501

High

273853

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

Small-scale

0.486

High

1037104

ZN626
Zinc finger protein 626

1

0

Small-scale

0.486

High

1037121

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

Small-scale

0.486

High

984082

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

Small-scale

0.481

High

1037110

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

1

High-throughput

0.481

High

822621

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.479

High

1037100

ELOC
Elongin-C

1

2

Small-scale

0.479

High

1037117

BOLA2
BolA-like protein 2

1

0

High-throughput

0.460

High

1037096

PAX5
Paired box protein Pax-5

1

0

Small-scale

0.458

High

1037101

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

1037098

MTG8
Protein CBFA2T1

1

5

High-throughput

0.457

High

1037109

TSC1
Hamartin

1

0

Small-scale

0.438

High

1037105

Q6FHM2
Epididymis secretory sperm binding protein

1

1

Small-scale

0.417

High

1037107

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

1037114

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

757

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

0

High-throughput

0.268

Low

109390

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

901194

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.268

Low

1037111

RND1
Rho-related GTP-binding protein Rho6

1

0

Small-scale

0.265

Low


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Last updated: 11Aug2025