Protein: ID2
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)

Gene: ID2
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q02363

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000791 - euchromatin
GO:0001656 - metanephros development
GO:0001779 - natural killer cell differentiation
GO:0001966 - thigmotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587448

TFE2
Transcription factor E2-alpha

10

20

Small-scale

0.978

High

587053

ITF2
Transcription factor 4

8

20

Small-scale

0.967

High

1036544

HTF4
Transcription factor 12

8

20

Small-scale

0.965

High

1036528

ASCL4
Achaete-scute homolog 4

3

20

High-throughput

0.858

High

868646

ID4
DNA-binding protein inhibitor ID-4

2

4

High-throughput

0.811

High

581643

MYOD1
Myoblast determination protein 1

2

13

Small-scale

0.800

High

65877

MSGN1
Mesogenin-1

2

16

High-throughput

0.783

High

1036540

PDLI5
PDZ and LIM domain protein 5

1

2

Small-scale

0.756

High

1036504

ID2
DNA-binding protein inhibitor ID-2

2

4

Small-scale

0.743

High

1036534

LMO3
LIM domain only protein 3

1

4

High-throughput

0.665

High

787859

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.647

High

675465

TYY1
Transcriptional repressor protein YY1

2

2

High-throughput

0.628

High

1036537

PHF3
PHD finger protein 3

2

1

High-throughput

0.628

High

442677

RB
Retinoblastoma-associated protein

2

3

Small-scale

0.624

High

253540

MUSC
Musculin

1

15

Small-scale

0.621

High

561209

MYF5
Myogenic factor 5

1

17

Small-scale

0.621

High

916082

NKX25
Homeobox protein Nkx-2.5

1

2

Small-scale

0.618

High

1036511

OLIG2
Oligodendrocyte transcription factor 2

1

17

Small-scale

0.618

High

1036533

OLIG1
Oligodendrocyte transcription factor 1

1

16

Small-scale

0.618

High

534951

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.614

High

270925

CLAP2
CLIP-associating protein 2

2

1

High-throughput

0.611

High

220234

FRS3
Fibroblast growth factor receptor substrate 3

2

1

High-throughput

0.606

High

667790

CDK2
Cyclin-dependent kinase 2

2

4

Small-scale

0.602

High

1036507

RBL2
Retinoblastoma-like protein 2

2

3

Small-scale

0.584

High

1036545

TCHP
Trichoplein keratin filament-binding protein

2

0

High-throughput

0.580

High

1036552

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1036553

FANCL
E3 ubiquitin-protein ligase FANCL

2

0

High-throughput

0.580

High

1036558

FZR1
Fizzy-related protein homolog

1

4

Small-scale

0.578

High

1036535

RIN3
Ras and Rab interactor 3

2

1

High-throughput

0.576

High

822620

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.561

High

851525

GATA4
Transcription factor GATA-4

1

2

Small-scale

0.561

High

1036513

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

Small-scale

0.561

High

1036518

ELOC
Elongin-C

1

2

Small-scale

0.561

High

1036562

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

6

Small-scale

0.561

High

1036527

CV039
Synaptic plasticity regulator PANTS

2

1

High-throughput

0.553

High

1036515

CASL
Enhancer of filamentation 1

1

1

Small-scale

0.552

High

1036526

TENS2
Tensin-2

2

0

High-throughput

0.551

High

718544

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.537

High

1036549

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.537

High

1036563

ASB4
Ankyrin repeat and SOCS box protein 4

1

0

Small-scale

0.537

High

1036505

DYST
Dystonin

1

1

High-throughput

0.536

High

1036546

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.536

High

1036559

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

1

High-throughput

0.536

High

1036512

PKD2
Polycystin-2

1

1

Small-scale

0.529

High

1036519

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

Small-scale

0.527

High

1036509

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1036514

FCL
GDP-L-fucose synthase

1

0

High-throughput

0.518

High

1036522

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

541444

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.515

High

656101

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.515

High

986353

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.515

High

1036516

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

High-throughput

0.515

High

1036538

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.515

High

329140

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.513

High

909307

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

0

High-throughput

0.513

High

936302

AFAD
Afadin

1

0

High-throughput

0.513

High

1036521

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

1036530

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.513

High

1036531

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.513

High

1036542

KI20B
Kinesin-like protein KIF20B

1

0

High-throughput

0.513

High

1036554

SLTM
SAFB-like transcription modulator

1

0

High-throughput

0.513

High

1036555

RBM27
RNA-binding protein 27

1

0

High-throughput

0.513

High

1036560

KLH20
Kelch-like protein 20

1

0

High-throughput

0.513

High

1036561

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.513

High

216420

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.508

High

691708

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.508

High

703541

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.508

High

1036541

ANM6
Protein arginine N-methyltransferase 6

1

1

High-throughput

0.508

High

1036550

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

2

High-throughput

0.508

High

443317

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

216670

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

603239

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.493

High

843495

HD
Huntingtin

1

0

High-throughput

0.493

High

966209

1433G
14-3-3 protein gamma

1

0

High-throughput

0.493

High

1036508

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

246542

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

853653

MK08
Mitogen-activated protein kinase 8

1

4

High-throughput

0.481

High

1036529

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.480

High

1036557

APC5
Anaphase-promoting complex subunit 5

1

0

Small-scale

0.480

High

162547

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.479

High

317163

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

457376

TBB5
Tubulin beta chain

1

1

Small-scale

0.479

High

537000

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

704944

RBL1
Retinoblastoma-like protein 1

1

3

Small-scale

0.479

High

761373

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

801274

HSPA9
Stress-70 protein, mitochondrial

1

5

Small-scale

0.479

High

942566

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

Small-scale

0.479

High

996666

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.479

High

997291

TBB4B
Tubulin beta-4B chain

1

1

Small-scale

0.479

High

1036510

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

1036520

E2F4
Transcription factor E2F4

1

1

Small-scale

0.479

High

1036551

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

Small-scale

0.479

High

1036524

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

194146

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

Small-scale

0.458

High

332502

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.458

High

1036506

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.458

High

1036517

STK38
Serine/threonine-protein kinase 38

1

0

Small-scale

0.458

High

1036536

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1036539

ELP4
Elongator complex protein 4

1

0

Small-scale

0.458

High

1036543

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

95693

E3W994
Cytoplasmic linker associated protein 2

1

1

High-throughput

0.445

High

1036525

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

1036547

FND11
Fibronectin type III domain-containing protein 11

2

0

High-throughput

0.316

High

1036548

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1036532

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.279

Low

1036556

CFDP1
Craniofacial development protein 1

1

0

High-throughput

0.279

Low

47318

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1036523

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025