HitPredict

Interactor 1: CSK22 (P19784)
Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
Gene: CSNK2A2

Interactor 2: CCNL1 (Q9UK58)
Cyclin-L1 (Cyclin-L)
Gene: CCNL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	33961781, 32707033, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 350 Hs			1 526
+	Hs
		934549 CSK21_HUMAN (1-348): 1.58e-124: 364: 81.36		CCNL1_HUMAN (1-526): 2.58e-109: 337: 100.00
+	Hs
		586932 CSK22_HUMAN (1-350): 5.04e-136: 392: 100.00		CCNL2_HUMAN (39-526): 6.46e-97: 305: 58.49
+	Hs
		934411 CSK21_HUMAN (1-348): 1.58e-124: 364: 81.36		CCNL2_HUMAN (39-526): 6.46e-97: 305: 58.49
+	Hs
		303826 CSK22_HUMAN (1-350): 5.04e-136: 392: 100.00		CCNB2_HUMAN (3-331): 1.23e-86: 274: 13.68
+	Hs
		538471 CDK2_HUMAN (37-331): 1.98e-123: 358: 29.74		CCNB1_HUMAN (7-328): 8.11e-92: 289: 14.37
+	Hs
		538521 CDK3_HUMAN (37-342): 1.78e-122: 356: 30.92		CCNB1_HUMAN (7-328): 8.11e-92: 289: 14.37
+	Hs
		303829 CDK2_HUMAN (37-331): 1.98e-123: 358: 29.74		CCNB2_HUMAN (3-331): 1.23e-86: 274: 13.68
+	Hs
		625350 CDK2_HUMAN (37-331): 1.98e-123: 358: 29.74		CCNA1_HUMAN (16-321): 1.03e-85: 274: 16.56
+	At
		1247203 Q9CAG1_ARATH (13-350): 3.83e-118: 360: 24.14		CCL11_ARATH (50-492): 1.63e-79: 256: 34.08
+	At
		1108309 Q9CAG1_ARATH (13-350): 3.83e-118: 360: 24.14		CCA34_ARATH (5-322): 1.66e-76: 247: 12.23
+	At
		621660 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCA23_ARATH (6-321): 2.12e-79: 257: 13.58
+	At
		621689 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCA32_ARATH (4-322): 1.97e-80: 257: 12.84
+	At
		48929 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCA33_ARATH (42-322): 1.01e-80: 256: 15.57
+	At
		621661 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCB12_ARATH (3-322): 6.08e-79: 255: 14.95
+	At
		621664 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCA34_ARATH (5-322): 1.66e-76: 247: 12.23
+	At
		621690 CDKA1_ARATH (37-329): 2.02e-119: 348: 29.61		CCA11_ARATH (43-324): 9.97e-75: 245: 13.54
+	Hs
		960107 CDK3_HUMAN (37-342): 1.78e-122: 356: 30.92		CCNQ_HUMAN (79-290): 2.47e-72: 232: 29.02
+	Hs
		624422 CDK3_HUMAN (37-342): 1.78e-122: 356: 30.92		CCNC_HUMAN (37-334): 2.01e-71: 231: 23.41
+	Hs
		625251 CDK2_HUMAN (37-331): 1.98e-123: 358: 29.74		CCNH_HUMAN (74-339): 1.91e-56: 193: 17.39
+	Hs
		851197 CDK3_HUMAN (37-342): 1.78e-122: 356: 30.92		CCNH_HUMAN (74-339): 1.91e-56: 193: 17.39