HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: DAXX (Q9UER7)
Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)
Gene: DAXX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

The method score is based on:

Property	Details
Experiments	10669754, 24550390, 29084956, 32545337, 12529400
Identification Methods	far western blotting, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 5 others more... GO:0006338 - chromatin remodeling GO:0010629 - negative regulation of gene expression GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	482
Hs

1	740

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024