HitPredict

Interactor 1: GNA12 (Q03113)
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
Gene: GNA12

Interactor 2: GBG8 (Q9UK08)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)
Gene: GNG8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 381 Hs			1 70
+	Hs
		482595 GNAO_HUMAN (25-380): 1.91e-173: 489: 41.85		GBG2_HUMAN (2-70): 8.65e-27: 94: 71.01
+	Hs
		482602 GNAO_HUMAN (25-380): 1.91e-173: 489: 41.85		GBG3_HUMAN (3-70): 4.1e-26: 92.4: 57.35
+	Hs
		948054 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG2_HUMAN (2-70): 8.65e-27: 94: 71.01
+	Hs
		482650 GNAO_HUMAN (25-380): 1.91e-173: 489: 41.85		GBG8_HUMAN (1-70): 9.21e-26: 91.3: 100.00
+	Hs
		893472 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG2_HUMAN (2-70): 8.65e-27: 94: 71.01
+	Hs
		989826 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG3_HUMAN (3-70): 4.1e-26: 92.4: 57.35
+	Hs
		893479 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG3_HUMAN (3-70): 4.1e-26: 92.4: 57.35
+	Hs
		989890 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG8_HUMAN (1-70): 9.21e-26: 91.3: 100.00
+	Hs
		893553 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG4_HUMAN (2-70): 1.82e-25: 90.9: 60.87
+	Hs
		893466 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG4_HUMAN (2-70): 1.82e-25: 90.9: 60.87
+	Hs
		482646 GNAO_HUMAN (25-380): 1.91e-173: 489: 41.85		GBG12_HUMAN (2-70): 4.1e-23: 84.7: 49.28
+	Hs
		243468 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG7_HUMAN (3-70): 1.04e-23: 86.2: 52.94
+	Hs
		989887 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG12_HUMAN (2-70): 4.1e-23: 84.7: 49.28
+	Hs
		893537 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG12_HUMAN (2-70): 4.1e-23: 84.7: 49.28
+	Hs
		482590 GNAO_HUMAN (25-380): 1.91e-173: 489: 41.85		GBG10_HUMAN (3-70): 1.98e-21: 80.5: 48.53
+	Hs
		893567 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG10_HUMAN (3-70): 1.98e-21: 80.5: 48.53
+	Hs
		893467 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG10_HUMAN (3-70): 1.98e-21: 80.5: 48.53
+	Hs
		989827 GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34		GBG5_HUMAN (3-70): 1.81e-20: 77.8: 44.12
+	Hs
		893480 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG5_HUMAN (3-70): 1.81e-20: 77.8: 44.12
+	Hs
		893478 GNAQ_HUMAN (22-380): 2.37e-172: 486: 42.90		GBG1_HUMAN (4-69): 4.77e-20: 77: 33.33