HitPredict

Interactor 1: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Interactor 2: GBG12 (Q9UBI6)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene: GNG12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35575683, 40437099
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 72
+	Hs
		243468 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG7_HUMAN (6-72): 3.32e-27: 95.1: 77.61
+	Hs
		989826 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG3_HUMAN (3-72): 1.94e-26: 93.2: 57.75
+	Hs
		948054 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG2_HUMAN (5-72): 3.26e-26: 92.8: 62.32
+	Hs
		476053 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG12_HUMAN (1-72): 2.15e-28: 98.2: 100.00
+	Hs
		893553 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG4_HUMAN (6-72): 2.01e-24: 88.2: 57.35
+	Hs
		989890 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG8_HUMAN (5-72): 2.89e-24: 87.8: 49.28
+	Hs
		893567 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG10_HUMAN (6-72): 4.06e-24: 87.4: 44.78
+	Hs
		243463 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG7_HUMAN (6-72): 3.32e-27: 95.1: 77.61
+	Hs
		475943 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG3_HUMAN (3-72): 1.94e-26: 93.2: 57.75
+	Hs
		989827 GNAI1_HUMAN (1-354): 0: 516: 100.00		GBG5_HUMAN (6-72): 9.89e-23: 83.6: 46.27
+	Hs
		243462 GNAI2_HUMAN (1-354): 2.64e-179: 502: 87.89		GBG7_HUMAN (6-72): 3.32e-27: 95.1: 77.61
+	Hs
		418646 GNAI2_HUMAN (1-354): 2.64e-179: 502: 87.89		GBG3_HUMAN (3-72): 1.94e-26: 93.2: 57.75
+	Hs
		475926 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG4_HUMAN (6-72): 2.01e-24: 88.2: 57.35
+	Hs
		418632 GNAI2_HUMAN (1-354): 2.64e-179: 502: 87.89		GBG2_HUMAN (5-72): 3.26e-26: 92.8: 62.32
+	Hs
		476058 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG8_HUMAN (5-72): 2.89e-24: 87.8: 49.28
+	Hs
		475927 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG10_HUMAN (6-72): 4.06e-24: 87.4: 44.78
+	Hs
		475944 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG5_HUMAN (6-72): 9.89e-23: 83.6: 46.27
+	Hs
		418625 GNAI2_HUMAN (1-354): 2.64e-179: 502: 87.89		GBG4_HUMAN (6-72): 2.01e-24: 88.2: 57.35
+	Hs
		418626 GNAI2_HUMAN (1-354): 2.64e-179: 502: 87.89		GBG10_HUMAN (6-72): 4.06e-24: 87.4: 44.78
+	Hs
		475935 GNAI3_HUMAN (1-354): 0: 507: 93.79		GBG11_HUMAN (13-71): 1.16e-18: 73.5: 44.07