HitPredict

Interactor 1: TRI14 (Q14142)
Tripartite motif-containing protein 14
Gene: TRIM14

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	24379373
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 442 Hs			1 729
+	Hs
		537119 TRI27_HUMAN (1-442): 2.34e-118: 357: 23.16		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Mm
		1143608 TRI27_MOUSE (1-442): 3.49e-118: 356: 23.16		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Hs
		585090 RO52_HUMAN (1-442): 3.23e-116: 350: 22.32		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		1318703 TRIM7_HUMAN (1-442): 1.17e-107: 329: 24.28		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		1354523 TRI10_HUMAN (1-440): 9.2e-94: 292: 18.78		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		536827 TRI27_HUMAN (1-442): 2.34e-118: 357: 23.16		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158386 TRI27_HUMAN (1-442): 2.34e-118: 357: 23.16		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		158392 RO52_HUMAN (1-442): 3.23e-116: 350: 22.32		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1050264 TRIM6_HUMAN (1-440): 4.35e-109: 332: 22.17		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		1050263 TRIM7_HUMAN (1-442): 1.17e-107: 329: 24.28		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		167459 TRI27_HUMAN (1-442): 2.34e-118: 357: 23.16		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		584875 RO52_HUMAN (1-442): 3.23e-116: 350: 22.32		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		167580 TRI22_HUMAN (1-442): 1.11e-105: 324: 19.01		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		1290895 TRI11_HUMAN (1-441): 3.73e-107: 326: 24.38		MARK1_HUMAN (9-407): 5.07e-87: 292: 23.33
+	Hs
		1318781 TRI39_HUMAN (1-442): 7.2e-131: 389: 25.22		DCLK3_HUMAN (14-238): 2.05e-22: 104: 29.78
+	Hs
		262230 TRI27_HUMAN (1-442): 2.34e-118: 357: 23.16		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Mm
		250797 TRI27_MOUSE (1-442): 3.49e-118: 356: 23.16		ULK1_MOUSE (13-222): 5.35e-26: 116: 33.64
+	Hs
		262235 RO52_HUMAN (1-442): 3.23e-116: 350: 22.32		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		183318 MEFV_HUMAN (12-442): 1.81e-111: 347: 20.14		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		883160 TRI68_HUMAN (1-441): 1.99e-112: 340: 21.03		HUNK_HUMAN (15-224): 1.07e-21: 102: 34.86