HitPredict

Interactor 1: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Interactor 2: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12771190, 15557335
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006915 - apoptotic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1009 Hs			1 868
+	Hs
		983641 FAK1_HUMAN (39-1000): 0: 846: 44.25		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		983667 FAK1_HUMAN (39-1000): 0: 846: 44.25		PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93
+	Hs
		523081 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		412278 FYN_HUMAN (288-695): 1.25e-116: 370: 29.68		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		433429 YES_HUMAN (288-695): 1.7e-116: 370: 28.71		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		442861 HCK_HUMAN (286-694): 3.05e-116: 369: 30.10		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Mm
		403468 SRC_MOUSE (288-695): 6.71e-116: 368: 27.98		PDC6I_MOUSE (1-868): 0: 638: 94.25
+	Hs
		523149 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93
+	Hs
		665375 EPHA3_HUMAN (380-701): 6.95e-116: 382: 33.13		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		111443 J3QRU1_HUMAN (288-695): 1.97e-116: 370: 28.71		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		412058 FYN_HUMAN (288-695): 1.25e-116: 370: 29.68		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		433272 YES_HUMAN (288-695): 1.7e-116: 370: 28.71		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		383844 ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96		TGO1_HUMAN (241-868): 3.47e-45: 178: 11.69
+	Hs
		523231 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		MYH4_HUMAN (137-704): 3.04e-51: 197: 11.80
+	Hs
		508046 FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08		TGO1_HUMAN (241-868): 3.47e-45: 178: 11.69
+	Hs
		411694 LCK_HUMAN (208-694): 1.45e-123: 387: 27.18		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Mm
		70886 SRC_MOUSE (288-695): 6.71e-116: 368: 27.98		EP300_MOUSE (527-864): 1.99e-35: 148: 13.58
+	Hs
		522942 SRC_HUMAN (288-695): 5.62e-117: 371: 27.74		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70