Interactor 1: ZO1 (Q07157)
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1
Interactor 2: ZO2 (Q9UDY2)
Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.963 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10575001, 9792688, 34079125, 35271311, 40437099, 10026224, 24255178 |
| Identification Methods | affinity chromatography technology, proximity labelling technology, cross-linking study, pull down, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_2, PDZ~PDZ, PDZ~SH3_2, SH3_2~SH3_2 |
| Common GO terms | GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005923 - bicellular tight junction GO:0035633 - maintenance of blood-brain barrier and 7 others more... |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
