HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.829

Property	Details
Experiments	9507002, 19166614, 12074588
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 594
+	Hs
		666119 NTRK2_HUMAN (1-822): 0: 638: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		1083860 NTRK2_HUMAN (1-822): 0: 638: 100.00		SHC4_HUMAN (1-593): 1.37e-158: 469: 43.61
+	Rn
		1129187 NTRK2_RAT (1-822): 0: 622: 93.55		SHC1_RAT (108-593): 5.71e-152: 447: 51.91
+	Hs
		666117 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		607889 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Mm
		957230 NTRK1_MOUSE (45-822): 2.04e-173: 521: 47.09		SHC1_MOUSE (3-593): 1.24e-176: 514: 47.55
+	Mm
		1112475 NTRK1_MOUSE (45-822): 2.04e-173: 521: 47.09		SHC3_MOUSE (121-593): 4.91e-161: 470: 91.33
+	Hs
		1083902 NTRK2_HUMAN (1-822): 0: 638: 100.00		SH2B1_HUMAN (302-594): 1.91e-56: 205: 20.70
+	Hs
		412212 NTRK2_HUMAN (1-822): 0: 638: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		924603 NTRK2_HUMAN (1-822): 0: 638: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		608068 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		ANS1A_HUMAN (11-377): 5.8e-54: 200: 15.78
+	Hs
		557707 NTRK2_HUMAN (1-822): 0: 638: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		607907 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		433576 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		607978 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		SHB_HUMAN (363-590): 9.97e-43: 162: 22.36
+	Rn
		71362 NTRK2_RAT (1-822): 0: 622: 93.55		B2RZ33_RAT (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		924601 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		607935 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		557705 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		557606 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56