HitPredict

Interactor 1: Q19350 (Q19350)
Drosophila CRumBs homolog
Gene: crb-1

Interactor 2: MUP4 (Q21281)
Transmembrane matrix receptor MUP-4 (Muscle-positioning protein 4)
Gene: mup-4

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	26780296, unassigned1274
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF~EGF, EGF~EGF_CA, EGF_3~EGF_CA, EGF_CA~EGF_CA, EGF~Laminin_G_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1722 Ce			1 2104
+	Ce
		712346 Q19350_CAEEL (1-1722): 0: 676: 100.00		MUA3_CAEEL (1132-1903): 4.48e-10: 67.5: 12.42
+	Hs
		980576 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		NOTC2_HUMAN (3-1137): 3.82e-59: 229: 12.91
+	Hs
		1357251 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		JAG2_HUMAN (1462-1906): 5.26e-29: 129: 13.27
+	Hs
		944134 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		JAG1_HUMAN (2-494): 1.23e-27: 124: 12.15
+	Hs
		804372 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		NOTC1_HUMAN (4-521): 4.27e-25: 117: 12.81
+	Hs
		1357250 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		NOTC3_HUMAN (3-504): 9.05e-20: 99.4: 13.73
+	Hs
		1059044 NOTC3_HUMAN (717-1719): 8.84e-89: 324: 18.13		LTBP1_HUMAN (1615-1848): 4.23e-14: 80.7: 23.31
+	Dm
		422709 NOTCH_DROME (975-1717): 4.21e-75: 280: 20.69		NOTCH_DROME (4-546): 1.5e-26: 121: 11.15
+	Dm
		90684 NOTCH_DROME (975-1717): 4.21e-75: 280: 20.69		E1JHA6_DROME (2-274): 4.58e-18: 94.1: 16.12
+	Hs
		980578 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		JAG2_HUMAN (1462-1906): 5.26e-29: 129: 13.27
+	Hs
		944119 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		JAG1_HUMAN (2-494): 1.23e-27: 124: 12.15
+	Hs
		804213 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		NOTC1_HUMAN (4-521): 4.27e-25: 117: 12.81
+	Hs
		724367 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		FBN2_HUMAN (4-557): 3.34e-23: 111: 13.56
+	Hs
		980445 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		LTBP4_HUMAN (3-721): 4.1e-17: 90.6: 13.34
+	Hs
		980375 NOTC2_HUMAN (1369-1718): 8.38e-30: 132: 22.91		LTBP1_HUMAN (1615-1848): 4.23e-14: 80.7: 23.31
+	Dr
		804161 NOTC1_DANRE (1372-1720): 4.62e-29: 129: 24.51		Q1A5L2_DANRE (1179-1323): 1.47e-10: 69.1: 19.31
+	Dr
		804162 NOTC1_DANRE (1372-1720): 4.62e-29: 129: 24.51		Q1A5L3_DANRE (81-420): 1.53e-09: 65.5: 23.81
+	Dr
		804160 NOTC1_DANRE (1372-1720): 4.62e-29: 129: 24.51		Q1A5L1_DANRE (1725-1854): 5.65e-09: 63.7: 22.96