HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TNR25 (Q93038)
Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)
Gene: TNFRSF25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21421854
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0042981 - regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 417
+	Hs
		622597 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR1A_HUMAN (29-413): 4.11e-75: 242: 27.18
+	Mm
		669406 TRAF2_MOUSE (1-501): 6.09e-157: 457: 86.83		TNR1A_MOUSE (29-414): 4.02e-70: 229: 26.44
+	Hs
		163290 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TR10B_HUMAN (27-413): 5.45e-58: 197: 18.66
+	Hs
		466571 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR16_HUMAN (24-409): 3.54e-54: 187: 16.99
+	Hs
		127673 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TR10A_HUMAN (24-413): 3.74e-51: 180: 16.29
+	Hs
		787544 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR3_HUMAN (5-312): 1.16e-45: 165: 14.29
+	Mm
		204645 TRAF2_MOUSE (1-501): 6.09e-157: 457: 86.83		TNR11_MOUSE (6-224): 4.77e-42: 158: 24.45
+	Hs
		1090834 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR14_HUMAN (14-263): 7.87e-42: 150: 23.77
+	Hs
		1091000 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR11_HUMAN (28-224): 7.45e-37: 143: 21.74
+	Hs
		630262 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR1B_HUMAN (2-316): 1.48e-36: 140: 17.93
+	Hs
		683232 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR5_HUMAN (1-259): 4.42e-36: 135: 18.18
+	Mm
		693155 TRAF2_MOUSE (1-501): 6.09e-157: 457: 86.83		TNR5_MOUSE (1-259): 4.55e-36: 135: 18.84
+	Mm
		811894 TRAF2_MOUSE (1-501): 6.09e-157: 457: 86.83		CD27_MOUSE (9-240): 9.57e-34: 128: 18.72
+	Hs
		689820 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		CD27_HUMAN (16-265): 2.93e-31: 122: 16.67
+	Hs
		705909 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR8_HUMAN (29-246): 2.08e-25: 110: 16.74
+	Hs
		1090928 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR27_HUMAN (33-143): 8e-23: 99.7: 21.24
+	Hs
		1090944 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR19_HUMAN (16-183): 6.58e-20: 93.1: 20.47
+	Mm
		630392 TRAF2_MOUSE (1-501): 6.09e-157: 457: 86.83		TNR9_MOUSE (42-209): 3.35e-20: 91.2: 17.54
+	Hs
		849432 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR4_HUMAN (41-164): 1.26e-17: 84.3: 18.52
+	Hs
		1057679 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		TNR9_HUMAN (48-186): 5.47e-10: 61.5: 20.57