HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: HOIL1 (Q9BYM8)
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)
Gene: RBCK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17006537
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 510
+	Hs
		1317101 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		HOIL1_HUMAN (1-510): 0: 577: 100.00
+	Hs
		919847 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HOIL1_HUMAN (1-510): 0: 577: 100.00
+	Hs
		1354303 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF14_HUMAN (242-478): 1.26e-68: 229: 18.99
+	Hs
		849498 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ARI1_HUMAN (216-496): 1.87e-68: 231: 18.09
+	Hs
		849474 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF14_HUMAN (242-478): 1.26e-68: 229: 18.99
+	Hs
		919891 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF14_HUMAN (242-478): 1.26e-68: 229: 18.99
+	Hs
		312679 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ARI2_HUMAN (243-496): 7.23e-65: 220: 19.85
+	Ce
		715114 UBC2_CAEEL (1-147): 7.45e-82: 239: 89.12		Q9XUS3_CAEEL (150-489): 1.62e-66: 221: 16.81
+	Hs
		312520 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ARI2_HUMAN (243-496): 7.23e-65: 220: 19.85
+	Hs
		312553 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ARI2_HUMAN (243-496): 7.23e-65: 220: 19.85
+	Hs
		919757 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN19B_HUMAN (277-477): 1.57e-57: 205: 22.97
+	Hs
		919876 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN19A_HUMAN (256-477): 5.57e-57: 205: 16.60
+	Hs
		1347205 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN216_HUMAN (235-497): 5.21e-52: 191: 19.13
+	Hs
		849460 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN216_HUMAN (235-497): 5.21e-52: 191: 19.13
+	Hs
		229121 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		919878 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN216_HUMAN (235-497): 5.21e-52: 191: 19.13
+	Hs
		226914 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		227093 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		842095 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		R144A_HUMAN (279-476): 3.85e-28: 115: 20.98
+	Hs
		842104 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		R144A_HUMAN (279-476): 3.85e-28: 115: 20.98