HitPredict

Interactor 1: HSPB3 (Q12988)
Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3)
Gene: HSPB3

Interactor 2: HSPB2 (Q16082)
Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) (Heat shock protein family B member 2)
Gene: HSPB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10625651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006986 - response to unfolded protein
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 182
+	Hs
		384421 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		HSPB2_HUMAN (1-164): 7.22e-56: 176: 100.00
+	Hs
		384350 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		CRYAA_HUMAN (5-174): 8.7e-56: 175: 34.30
+	Hs
		415596 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB2_HUMAN (1-164): 7.22e-56: 176: 100.00
+	Hs
		384351 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		CRYAB_HUMAN (6-174): 1e-54: 172: 35.67
+	Hs
		384353 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		HSPB1_HUMAN (1-179): 4.45e-54: 172: 32.85
+	Hs
		384595 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		V9HW27_HUMAN (6-174): 1e-54: 172: 35.67
+	Hs
		384604 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		CRYAB_HUMAN (6-174): 1e-54: 172: 35.67
+	Hs
		415264 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB1_HUMAN (1-179): 4.45e-54: 172: 32.85
+	Bt
		384349 CRYAB_BOVIN (13-149): 2.62e-48: 155: 27.74		CRYAA_BOVIN (6-174): 3.83e-53: 168: 33.33
+	Rn
		663485 CRYAB_RAT (13-149): 1.59e-48: 155: 27.01		HSPB1_RAT (1-179): 6.13e-51: 164: 29.81
+	Hs
		156385 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB6_HUMAN (6-144): 2.25e-41: 138: 40.28
+	Dm
		384790 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP26_DROME (36-178): 1.26e-40: 137: 23.68
+	Hs
		1092307 HSPB3_HUMAN (1-150): 5.55e-48: 153: 100.00		HSPB8_HUMAN (1-170): 4.73e-38: 130: 25.00
+	Hs
		415924 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB8_HUMAN (1-170): 4.73e-38: 130: 25.00
+	Dm
		384791 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP27_DROME (4-179): 9.3e-34: 120: 25.63
+	Dm
		384796 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP6C_DROME (69-182): 1.03e-33: 120: 32.52
+	Dm
		384755 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP22_DROME (33-175): 4.49e-33: 117: 22.60