HitPredict

Interactor 1: HSPB3 (Q12988)
Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3)
Gene: HSPB3

Interactor 2: HSPB8 (Q9UJY1)
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
Gene: HSPB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	16225851
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 196
+	Hs
		415924 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB8_HUMAN (1-196): 1.66e-69: 211: 100.00
+	Hs
		384353 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		HSPB1_HUMAN (1-179): 2.04e-61: 191: 36.67
+	Hs
		415264 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB1_HUMAN (1-179): 2.04e-61: 191: 36.67
+	Rn
		663485 CRYAB_RAT (13-149): 1.59e-48: 155: 27.01		HSPB1_RAT (1-179): 2.03e-59: 186: 36.41
+	Hs
		384351 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		CRYAB_HUMAN (6-187): 3.85e-53: 169: 31.69
+	Hs
		384595 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		V9HW27_HUMAN (6-187): 3.85e-53: 169: 31.69
+	Hs
		384350 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		CRYAA_HUMAN (6-187): 2.14e-52: 167: 23.53
+	Hs
		384604 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		CRYAB_HUMAN (6-187): 3.85e-53: 169: 31.69
+	Bt
		384349 CRYAB_BOVIN (13-149): 2.62e-48: 155: 27.74		CRYAA_BOVIN (6-188): 5.74e-51: 163: 24.47
+	Dm
		384790 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP26_DROME (10-193): 1.82e-48: 158: 21.20
+	Hs
		156385 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB6_HUMAN (5-166): 4.25e-45: 148: 31.10
+	Hs
		384421 CRYAA_HUMAN (13-145): 1.98e-48: 155: 30.83		HSPB2_HUMAN (1-170): 5.38e-42: 141: 25.88
+	Hs
		1092295 HSPB3_HUMAN (1-150): 5.55e-48: 153: 100.00		HSPB2_HUMAN (1-170): 5.38e-42: 141: 25.88
+	Hs
		415596 HSPB1_HUMAN (14-147): 4.72e-47: 153: 28.08		HSPB2_HUMAN (1-170): 5.38e-42: 141: 25.88
+	Dm
		384791 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP27_DROME (8-192): 3.43e-40: 137: 27.51
+	Dm
		384796 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP6C_DROME (91-193): 9.83e-34: 120: 29.13
+	Dm
		384755 HSP23_DROME (1-150): 5.53e-48: 154: 29.14		HSP22_DROME (21-192): 8.2e-32: 114: 23.56