HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: RCOR2 (Q8IZ40)
REST corepressor 2
Gene: RCOR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	28514442, 33961781, 34709266, 23752268, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003714 - transcription corepressor activity GO:0006357 - regulation of transcription by RNA polymerase II GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 523
+	Hs
		1110137 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR3_HUMAN (46-520): 8.74e-129: 386: 57.20
+	Mm
		148739 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA2_MOUSE (12-512): 8.71e-104: 327: 17.14
+	Mm
		148723 HDAC1_MOUSE (1-482): 0: 672: 99.38		RCOR1_MOUSE (16-425): 1.85e-103: 320: 51.43
+	Hs
		316845 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA2_HUMAN (12-512): 1.28e-102: 324: 17.50
+	Hs
		316935 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA2_HUMAN (12-512): 1.28e-102: 324: 17.50
+	Hs
		1110170 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR1_HUMAN (16-425): 1.8e-102: 318: 51.44
+	Mm
		148724 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA1_MOUSE (26-474): 3.03e-98: 314: 16.80
+	Hs
		1102528 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA1_HUMAN (26-474): 1.91e-97: 311: 17.00
+	Hs
		1102617 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA1_HUMAN (26-474): 1.91e-97: 311: 17.00
+	Hs
		1110039 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA3_HUMAN (17-421): 6.33e-95: 302: 15.66
+	Hs
		95906 HDAC1_HUMAN (1-482): 0: 668: 100.00		E7EQY4_HUMAN (17-359): 3.54e-91: 290: 18.55
+	Hs
		278336 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR1_HUMAN (81-522): 1.28e-66: 236: 16.03
+	Hs
		1110139 HDAC1_HUMAN (1-482): 0: 668: 100.00		RERE_HUMAN (5-522): 2.55e-62: 223: 17.11
+	Hs
		1109844 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER3_HUMAN (2-233): 1.27e-60: 210: 22.05
+	Mm
		148713 HDAC1_MOUSE (1-482): 0: 672: 99.38		RERE_MOUSE (5-521): 4.4e-56: 205: 16.95
+	Hs
		1277269 HDAC2_HUMAN (1-478): 0: 666: 85.92		MIER3_HUMAN (2-233): 1.27e-60: 210: 22.05
+	Hs
		1109884 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER1_HUMAN (2-349): 3.52e-57: 200: 17.60
+	Hs
		1109999 HDAC1_HUMAN (1-482): 0: 668: 100.00		TREF1_HUMAN (14-305): 1.45e-31: 131: 22.15
+	Hs
		1109893 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER2_HUMAN (332-522): 1.01e-14: 78.9: 17.23
+	Hs
		1110224 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR2_HUMAN (133-521): 1.51e-11: 69.3: 10.24