HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: RCOR1 (Q8CFE3)
REST corepressor 1 (Protein CoREST)
Gene: RCOR1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	22297846, 24240174
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0003682 - chromatin binding GO:0003714 - transcription corepressor activity GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0017053 - transcription repressor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 480
+	Hs
		1110170 HDAC1_HUMAN (1-482): 0: 666: 99.38		RCOR1_HUMAN (1-480): 1.63e-144: 424: 90.95
+	Hs
		1110137 HDAC1_HUMAN (1-482): 0: 666: 99.38		RCOR3_HUMAN (99-475): 2.87e-125: 375: 64.19
+	Hs
		1109880 HDAC1_HUMAN (1-482): 0: 666: 99.38		RCOR2_HUMAN (55-474): 5.15e-114: 347: 52.56
+	Hs
		1110039 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA3_HUMAN (11-411): 3.68e-99: 311: 16.67
+	Hs
		95906 HDAC1_HUMAN (1-482): 0: 666: 99.38		E7EQY4_HUMAN (11-411): 3.7e-99: 309: 16.44
+	Hs
		1109999 HDAC1_HUMAN (1-482): 0: 666: 99.38		TREF1_HUMAN (7-411): 1.79e-78: 267: 17.12
+	Mm
		148739 HDAC1_MOUSE (1-482): 0: 670: 100.00		MTA2_MOUSE (12-407): 1.14e-78: 259: 14.87
+	Hs
		316845 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA2_HUMAN (12-407): 6.15e-78: 258: 15.10
+	Mm
		148724 HDAC1_MOUSE (1-482): 0: 670: 100.00		MTA1_MOUSE (31-407): 8.56e-76: 253: 15.48
+	Hs
		1102528 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA1_HUMAN (31-407): 9.3e-77: 256: 15.00
+	Hs
		316935 HDAC2_HUMAN (1-478): 0: 664: 86.13		MTA2_HUMAN (12-407): 6.15e-78: 258: 15.10
+	Hs
		1102617 HDAC2_HUMAN (1-478): 0: 664: 86.13		MTA1_HUMAN (31-407): 9.3e-77: 256: 15.00
+	Hs
		1110224 HDAC1_HUMAN (1-482): 0: 666: 99.38		NCOR2_HUMAN (135-474): 1.44e-73: 254: 20.82
+	Hs
		1109884 HDAC1_HUMAN (1-482): 0: 666: 99.38		MIER1_HUMAN (24-397): 1.27e-71: 237: 15.04
+	Hs
		1110139 HDAC1_HUMAN (1-482): 0: 666: 99.38		RERE_HUMAN (35-470): 1.21e-62: 222: 17.36
+	Hs
		1109827 HDAC1_HUMAN (1-482): 0: 666: 99.38		MDEAS_HUMAN (15-397): 1.26e-62: 221: 16.47
+	Mm
		148713 HDAC1_MOUSE (1-482): 0: 670: 100.00		RERE_MOUSE (35-470): 6.67e-61: 217: 17.36
+	Hs
		1109844 HDAC1_HUMAN (1-482): 0: 666: 99.38		MIER3_HUMAN (32-291): 6.54e-62: 212: 21.15
+	Hs
		1109893 HDAC1_HUMAN (1-482): 0: 666: 99.38		MIER2_HUMAN (40-278): 2.07e-51: 184: 21.71
+	Hs
		278336 HDAC1_HUMAN (1-482): 0: 666: 99.38		NCOR1_HUMAN (188-383): 6.34e-11: 67.3: 17.77