HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: WSB1 (Q9Y6I7)
WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
Gene: WSB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36688959, 17079684
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 421
+	Hs
		845297 CUL4A_HUMAN (1-759): 0: 958: 100.00		LIS1_HUMAN (2-286): 4.13e-84: 264: 20.72
+	Hs
		845298 CUL4B_HUMAN (10-759): 0: 922: 82.31		LIS1_HUMAN (2-286): 4.13e-84: 264: 20.72
+	Hs
		1114994 CUL4A_HUMAN (1-759): 0: 958: 100.00		SNR40_HUMAN (2-282): 3.49e-66: 216: 20.42
+	Hs
		1115343 CUL4B_HUMAN (10-759): 0: 922: 82.31		FBXW7_HUMAN (2-334): 6e-76: 251: 19.05
+	Hs
		1114950 CUL4A_HUMAN (1-759): 0: 958: 100.00		POC1B_HUMAN (208-421): 1.21e-60: 205: 21.46
+	Hs
		1115353 CUL4B_HUMAN (10-759): 0: 922: 82.31		SNR40_HUMAN (2-282): 3.49e-66: 216: 20.42
+	Hs
		1115313 CUL4B_HUMAN (10-759): 0: 922: 82.31		POC1B_HUMAN (208-421): 1.21e-60: 205: 21.46
+	Hs
		921886 CUL4A_HUMAN (1-759): 0: 958: 100.00		COPA_HUMAN (206-381): 7.86e-34: 136: 18.54
+	Hs
		964928 CUL4A_HUMAN (1-759): 0: 958: 100.00		WDR5_HUMAN (295-420): 4.98e-31: 123: 15.27
+	Hs
		1115101 CUL4A_HUMAN (1-759): 0: 958: 100.00		WSB2_HUMAN (2-198): 7.5e-29: 118: 15.50
+	Hs
		1114921 CUL4A_HUMAN (1-759): 0: 958: 100.00		WDR5B_HUMAN (285-420): 3.61e-27: 112: 13.48
+	Hs
		964929 CUL4B_HUMAN (10-759): 0: 922: 82.31		WDR5_HUMAN (295-420): 4.98e-31: 123: 15.27
+	Hs
		1115283 CUL4B_HUMAN (10-759): 0: 922: 82.31		WDR5B_HUMAN (285-420): 3.61e-27: 112: 13.48
+	Hs
		1113779 CUL3_HUMAN (32-759): 0: 810: 38.23		POC1B_HUMAN (208-421): 1.21e-60: 205: 21.46
+	Hs
		261407 CUL4B_HUMAN (10-759): 0: 922: 82.31		TBL1X_HUMAN (289-418): 8.11e-19: 90.5: 13.42
+	Hs
		1115406 CUL4B_HUMAN (10-759): 0: 922: 82.31		TBL1R_HUMAN (289-418): 4.1e-18: 88.2: 14.19
+	Hs
		1113186 CUL3_HUMAN (32-759): 0: 810: 38.23		TAF5_HUMAN (206-382): 7.74e-36: 142: 20.08
+	Hs
		921885 CUL3_HUMAN (32-759): 0: 810: 38.23		COPA_HUMAN (206-381): 7.86e-34: 136: 18.54
+	Hs
		964927 CUL3_HUMAN (32-759): 0: 810: 38.23		WDR5_HUMAN (295-420): 4.98e-31: 123: 15.27
+	Hs
		1114438 CUL3_HUMAN (32-759): 0: 810: 38.23		NLE1_HUMAN (301-418): 8.31e-29: 119: 19.38