HitPredict

Interactor 1: AVR2B (Q13705)
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Gene: ACVR2B

Interactor 2: GDF2 (Q9UK05)
Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
Gene: GDF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22718755
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0006879 - intracellular iron ion homeostasis GO:0030509 - BMP signaling pathway GO:0032924 - activin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 429
+	Hs
		611727 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		BMP7_HUMAN (51-428): 1.93e-115: 346: 23.54
+	Hs
		335549 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		BMP10_HUMAN (53-429): 1.53e-114: 343: 41.78
+	Hs
		611705 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		BMP7_HUMAN (51-428): 1.93e-115: 346: 23.54
+	Hs
		335539 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		BMP10_HUMAN (53-429): 1.53e-114: 343: 41.78
+	Hs
		643196 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		BMP6_HUMAN (18-428): 1.93e-107: 328: 26.39
+	Hs
		554131 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		BMP2_HUMAN (26-429): 2.25e-106: 321: 25.72
+	Hs
		643190 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		BMP6_HUMAN (18-428): 1.93e-107: 328: 26.39
+	Hs
		554124 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		BMP2_HUMAN (26-429): 2.25e-106: 321: 25.72
+	Hs
		554158 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		BMP4_HUMAN (29-429): 7.62e-104: 315: 26.76
+	Hs
		845234 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		GDF5_HUMAN (18-429): 3.66e-96: 299: 23.19
+	Hs
		690076 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		GDF5_HUMAN (18-429): 3.66e-96: 299: 23.19
+	Hs
		470369 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		INHBA_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		62228 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		A4D1W7_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		164764 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		GDF8_HUMAN (43-428): 1.13e-84: 265: 20.35
+	Hs
		470363 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		INHBA_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		1116838 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		NODAL_HUMAN (69-428): 3.33e-76: 242: 27.40
+	Hs
		335387 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		GDF11_HUMAN (31-428): 2.02e-73: 237: 19.57
+	Hs
		690120 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		NODAL_HUMAN (69-428): 3.33e-76: 242: 27.40
+	Hs
		483487 AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00		INHBB_HUMAN (39-428): 2.85e-71: 232: 20.96
+	Hs
		483484 AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32		INHBB_HUMAN (39-428): 2.85e-71: 232: 20.96