HitPredict

Interactor 1: INHBA (P08476)
Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
Gene: INHBA

Interactor 2: AVR2B (Q13705)
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Gene: ACVR2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	9202237, 22267736, 8242742, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0032924 - activin receptor signaling pathway GO:0060021 - roof of mouth development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 426 Hs			1 512
+	Hs
		62228 A4D1W7_HUMAN (1-426): 6.72e-167: 477: 100.00		AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00
+	Hs
		470363 INHBA_HUMAN (1-426): 6.72e-167: 477: 100.00		AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32
+	Mm
		690144 INHBA_MOUSE (1-426): 2.25e-167: 478: 96.01		AVR2A_MOUSE (3-512): 3.02e-150: 441: 67.12
+	Mm
		690148 INHBA_MOUSE (1-426): 2.25e-167: 478: 96.01		AVR2B_MOUSE (1-512): 5.75e-148: 436: 93.66
+	Hs
		470368 INHBA_HUMAN (1-426): 6.72e-167: 477: 100.00		ACVR1_HUMAN (39-492): 3.03e-134: 400: 30.39
+	Hs
		470370 INHBA_HUMAN (1-426): 6.72e-167: 477: 100.00		BMPR2_HUMAN (4-502): 2.56e-122: 384: 33.84
+	Hs
		470366 INHBA_HUMAN (1-426): 6.72e-167: 477: 100.00		ACVL1_HUMAN (48-484): 2.29e-114: 348: 30.93
+	Hs
		470365 INHBA_HUMAN (1-426): 6.72e-167: 477: 100.00		ACV1B_HUMAN (3-481): 6.82e-110: 337: 28.88
+	Mm
		1050144 INHBA_MOUSE (1-426): 2.25e-167: 478: 96.01		ACV1B_MOUSE (3-481): 4.69e-109: 335: 29.47
+	Hs
		611727 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00
+	Hs
		483487 INHBB_HUMAN (31-426): 2.65e-106: 321: 41.35		AVR2B_HUMAN (1-512): 5.64e-154: 450: 100.00
+	Hs
		611705 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32
+	Hs
		483484 INHBB_HUMAN (31-426): 2.65e-106: 321: 41.35		AVR2A_HUMAN (3-512): 1.46e-150: 442: 67.32
+	Hs
		611723 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		ACVR1_HUMAN (39-492): 3.03e-134: 400: 30.39
+	Hs
		611728 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		BMPR2_HUMAN (4-502): 2.56e-122: 384: 33.84
+	Hs
		128526 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		BMR1B_HUMAN (58-486): 1.95e-126: 380: 32.39
+	Hs
		483488 INHBB_HUMAN (31-426): 2.65e-106: 321: 41.35		BMPR2_HUMAN (4-502): 2.56e-122: 384: 33.84
+	Hs
		128524 BMP2_HUMAN (26-425): 1.11e-104: 317: 23.59		BMR1B_HUMAN (58-486): 1.95e-126: 380: 32.39
+	Hs
		611710 BMP7_HUMAN (48-425): 3.24e-108: 327: 19.46		BMR1A_HUMAN (58-486): 1.17e-117: 358: 30.02
+	Hs
		483485 INHBB_HUMAN (31-426): 2.65e-106: 321: 41.35		ACV1B_HUMAN (3-481): 6.82e-110: 337: 28.88