HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2472 Hs			1 1620
+	Hs
		1132358 GOGB1_HUMAN (6-1182): 3.16e-40: 167: 10.59		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1028908 SPTB2_HUMAN (756-2418): 1.66e-38: 161: 16.65		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1040402 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		883961 CENPF_HUMAN (1723-2418): 1.13e-14: 83.1: 11.64		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		224828 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		411900 SPTN1_HUMAN (1-2472): 0: 707: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		711891 GOGB1_HUMAN (6-1182): 3.16e-40: 167: 10.59		LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24
+	Hs
		711871 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24
+	Hs
		641159 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24
+	Hs
		710621 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		EPHA3_HUMAN (943-1427): 1.05e-119: 403: 25.05
+	Rn
		92853 D3ZC56_RAT (146-1101): 6.72e-14: 80.5: 11.32		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		411752 SPTB2_HUMAN (756-2418): 1.66e-38: 161: 16.65		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1040305 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		411771 DYST_HUMAN (76-2405): 5.56e-33: 143: 9.90		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		456106 PLEC_HUMAN (1-1120): 1.77e-30: 135: 10.57		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	Hs
		541498 PLEC_HUMAN (1-1120): 1.77e-30: 135: 10.57		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		411273 ACTN1_HUMAN (1862-2210): 3.17e-11: 71.2: 22.25		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		224579 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07