HitPredict

Interactor 1: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 7570 Hs			1 1620
+	Hs
		711871 DYST_HUMAN (1-7570): 0: 2655: 100.00		LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24
+	Hs
		641159 DYST_HUMAN (1-7570): 0: 2655: 100.00		FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24
+	Hs
		710621 DYST_HUMAN (1-7570): 0: 2655: 100.00		EPHA3_HUMAN (943-1427): 1.05e-119: 403: 25.05
+	Hs
		1040305 DYST_HUMAN (1-7570): 0: 2655: 100.00		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		411771 DYST_HUMAN (1-7570): 0: 2655: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Rn
		92853 D3ZC56_RAT (1-7570): 0: 2462: 78.85		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		1028908 SPTB2_HUMAN (5667-7517): 1.67e-28: 130: 12.81		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		883961 CENPF_HUMAN (206-972): 1.08e-14: 84.8: 10.43		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1117526 SPTN1_HUMAN (269-874): 2.35e-13: 80.3: 13.42		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Rn
		108156 UTRN_RAT (326-1666): 3.87e-59: 231: 14.31		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		650082 UTRN_HUMAN (256-1575): 2.02e-27: 127: 12.54		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Hs
		179622 SYNE1_HUMAN (299-1798): 1.65e-14: 84.4: 10.03		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		477222 EPIPL_HUMAN (1610-1890): 6.68e-13: 79: 19.22		ROS1_HUMAN (1039-1461): 3.97e-112: 397: 37.75
+	Hs
		411752 SPTB2_HUMAN (5667-7517): 1.67e-28: 130: 12.81		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541390 UTRN_HUMAN (256-1575): 2.02e-27: 127: 12.54		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		412282 SYNE1_HUMAN (299-1798): 1.65e-14: 84.4: 10.03		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411273 ACTN1_HUMAN (3594-4065): 3.52e-14: 82.5: 8.73		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411900 SPTN1_HUMAN (269-874): 2.35e-13: 80.3: 13.42		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		456106 PLEC_HUMAN (1777-1974): 7.67e-14: 82.1: 19.19		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	Hs
		541498 PLEC_HUMAN (1777-1974): 7.67e-14: 82.1: 19.19		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07