Interactor 1: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Interactor 2: ITPR1 (Q14643)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
Gene: ITPR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 35271311
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ins145_P3_rec~Ins145_P3_rec, Ins145_P3_rec~MIR, Ins145_P3_rec~RIH_assoc, Ins145_P3_rec~RYDR_ITPR, Ion_trans~Ion_trans, MIR~MIR, MIR~RYDR_ITPR, RYDR_ITPR~RYDR_ITPR
Common GO terms GO:0005220 - inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding
GO:0005730 - nucleolus
GO:0005783 - endoplasmic reticulum
and 12 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 2671
Hs

1 2758
+ Hs
+ Hs
+ Mm
+ Rn
+ Dm
+ Ce
+ Hs
+ Oc
+ Mm
+ Hs
+ Mm
+ Hs
+ Oc
+ Hs

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Last updated: 11Aug2025