HitPredict

Interactor 1: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Interactor 2: SYNE3 (Q6ZMZ3)
Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)
Gene: SYNE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~Spectrin, SH3_10~Spectrin, Spectrin~Spectrin_3
Common GO terms	GO:0051015 - actin filament binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 4684 Hs			1 975
+	Hs
		772814 PLEC_HUMAN (1-4684): 0: 1793: 100.00		MYH9_HUMAN (2-691): 1.9e-22: 106: 9.68
+	Hs
		1117369 PLEC_HUMAN (1-4684): 0: 1793: 100.00		SPTN1_HUMAN (181-883): 5.88e-22: 105: 13.75
+	Hs
		386468 PLEC_HUMAN (1-4684): 0: 1793: 100.00		SPTA1_HUMAN (5-651): 8.88e-17: 88.1: 11.36
+	Hs
		1143304 PLEC_HUMAN (1-4684): 0: 1793: 100.00		MACF1_HUMAN (9-917): 2.94e-14: 79.9: 12.37
+	Hs
		1040296 PLEC_HUMAN (1-4684): 0: 1793: 100.00		DYST_HUMAN (5-774): 8.84e-13: 75.2: 9.52
+	Mm
		547402 PLEC_MOUSE (1-4684): 0: 1757: 93.27		DMD_MOUSE (324-884): 1.16e-10: 68.1: 12.52
+	Hs
		555621 ACTN1_HUMAN (153-894): 1.99e-116: 396: 23.90		MYH9_HUMAN (2-691): 1.9e-22: 106: 9.68
+	Rn
		591445 ACTN1_RAT (153-894): 2.1e-116: 396: 24.03		SPTN1_RAT (181-883): 2e-22: 106: 13.89
+	Rn
		1251028 ACTN1_RAT (153-894): 2.1e-116: 396: 24.03		Q6XD99_RAT (7-847): 5.68e-14: 79.1: 15.88
+	Dm
		612379 ACTN_DROME (156-894): 5.82e-121: 410: 23.24		Q71JA7_DROME (169-904): 8.36e-09: 61.9: 9.99
+	Rn
		591442 Q6XD99_RAT (1005-2737): 1.04e-31: 140: 11.13		SPTN1_RAT (181-883): 2e-22: 106: 13.89
+	Hs
		772748 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		MYH9_HUMAN (2-691): 1.9e-22: 106: 9.68
+	Hs
		1028762 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		SPTN1_HUMAN (181-883): 5.88e-22: 105: 13.75
+	Mm
		1223935 SPTB2_MOUSE (1005-2737): 1.53e-30: 136: 10.11		SPTB2_MOUSE (5-704): 2.11e-20: 100: 12.94
+	Hs
		1028869 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		SPTN4_HUMAN (6-825): 3.78e-18: 92.7: 13.61
+	Hs
		386461 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		SPTA1_HUMAN (5-651): 8.88e-17: 88.1: 11.36
+	Hs
		1028730 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		SPTB2_HUMAN (7-847): 9.1e-17: 87.9: 15.19
+	Hs
		174713 SPTN2_HUMAN (1390-3107): 3.29e-22: 108: 12.11		MYH9_HUMAN (2-691): 1.9e-22: 106: 9.68
+	Hs
		174744 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		SPTN2_HUMAN (5-282): 6.11e-12: 72.3: 13.31