HitPredict

Interactor 1: PWP2 (Q15269)
Periodic tryptophan protein 2 homolog
Gene: PWP2

Interactor 2: WDR36 (Q8NI36)
WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)
Gene: WDR36

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Utp12~Utp21
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0032040 - small-subunit processome GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome GO:0042274 - ribosomal small subunit biogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 919 Hs			1 895
+	Dm
		1216731 Q5U0X8_DROME (1-918): 3.7e-170: 521: 45.01		Q9VFV8_DROME (2-892): 9.61e-143: 448: 38.88
+	Sc
		678461 PWP2_YEAST (1-889): 0: 558: 41.74		UTP21_YEAST (2-893): 7.88e-128: 409: 29.51
+	Hs
		1341169 WDR3_HUMAN (1-578): 1.22e-94: 321: 13.04		WDR36_HUMAN (1-895): 0: 584: 100.00
+	Sc
		678460 PWP2_YEAST (1-889): 0: 558: 41.74		UTP13_YEAST (88-639): 3.08e-50: 192: 17.28
+	Dm
		1216730 Q5U0X8_DROME (1-918): 3.7e-170: 521: 45.01		Q9VE98_DROME (6-305): 7.56e-47: 183: 13.67
+	Hs
		1144753 PWP2_HUMAN (1-919): 0: 589: 100.00		WDR3_HUMAN (536-770): 7.3e-25: 113: 16.21
+	Hs
		1341154 NLE1_HUMAN (576-790): 2.33e-27: 118: 10.41		WDR36_HUMAN (1-895): 0: 584: 100.00
+	Dm
		1216729 Q5U0X8_DROME (1-918): 3.7e-170: 521: 45.01		Q7JQT9_DROME (18-462): 4.37e-41: 164: 12.82
+	Hs
		1085660 PWP2_HUMAN (1-919): 0: 589: 100.00		TBL3_HUMAN (2-93): 1.46e-10: 67.2: 9.28
+	Sc
		678486 PWP2_YEAST (1-889): 0: 558: 41.74		UTP12_YEAST (24-99): 3.2e-09: 63: 10.13
+	Hs
		1085730 WDR3_HUMAN (1-578): 1.22e-94: 321: 13.04		TBL3_HUMAN (2-93): 1.46e-10: 67.2: 9.28
+	Dm
		1463899 WDS_DROME (489-792): 4.13e-60: 210: 13.07		WDS_DROME (18-222): 1.34e-38: 149: 13.95
+	Hs
		773471 WDR5_HUMAN (1-125): 9.82e-24: 105: 9.66		COPB2_HUMAN (269-592): 4.81e-51: 195: 9.45
+	Dm
		264647 COPB2_DROME (3-394): 4.04e-40: 162: 7.46		Q9W0B8_DROME (559-719): 3.61e-25: 114: 13.10
+	Hs
		845346 LIS1_HUMAN (96-403): 5.87e-37: 146: 14.89		KTNB1_HUMAN (275-577): 1.28e-28: 124: 16.34
+	Hs
		1450936 NLE1_HUMAN (576-790): 2.33e-27: 118: 10.41		NLE1_HUMAN (522-744): 3.85e-30: 127: 14.35
+	Hs
		845264 LIS1_HUMAN (96-403): 5.87e-37: 146: 14.89		WDR5_HUMAN (558-691): 1.89e-21: 98.6: 19.26
+	Hs
		921858 WDR5_HUMAN (1-125): 9.82e-24: 105: 9.66		COPA_HUMAN (559-732): 4.56e-25: 114: 12.71
+	Hs
		965276 NLE1_HUMAN (576-790): 2.33e-27: 118: 10.41		WDR5_HUMAN (558-691): 1.89e-21: 98.6: 19.26
+	Hs
		964797 WDR5_HUMAN (1-125): 9.82e-24: 105: 9.66		WDR5_HUMAN (558-691): 1.89e-21: 98.6: 19.26