Protein: UTP21
U3 small nucleolar RNA-associated protein 21 (U3 snoRNA-associated protein 21) (U three protein 21)

Gene: UTP21
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: Q06078

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0030490 - maturation of SSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678461

PWP2
Periodic tryptophan protein 2

16

17

Small-scale

0.987

High

1053537

UTP12
U3 small nucleolar RNA-associated protein 12

7

18

Small-scale

0.967

High

1053108

UTP13
U3 small nucleolar RNA-associated protein 13

6

19

Small-scale

0.940

High

1045106

UTP5
U3 small nucleolar RNA-associated protein 5

2

19

High-throughput

0.793

High

823387

UTP18
U3 small nucleolar RNA-associated protein 18

15

4

Small-scale

0.764

High

1036410

UTP6
U3 small nucleolar RNA-associated protein 6

10

5

Small-scale

0.758

High

677567

KRR1
KRR1 small subunit processome component

6

2

Small-scale

0.732

High

844615

UTP10
U3 small nucleolar RNA-associated protein 10

6

6

Small-scale

0.730

High

798312

ENP1
Essential nuclear protein 1

6

3

Small-scale

0.726

High

918825

UTP22
U3 small nucleolar RNA-associated protein 22

5

3

Small-scale

0.716

High

1053542

NOP58
Nucleolar protein 58

5

12

Small-scale

0.714

High

1053521

UTP4
U3 small nucleolar RNA-associated protein 4

5

18

Small-scale

0.709

High

1046033

DHR1
Probable ATP-dependent RNA helicase DHR1

5

3

Small-scale

0.702

High

1053518

NOC4
Nucleolar complex protein 4

5

7

Small-scale

0.702

High

817632

UTP7
U3 small nucleolar RNA-associated protein 7

4

19

High-throughput

0.697

High

1053534

SAS10
Something about silencing protein 10

4

2

Small-scale

0.691

High

865173

MPP10
U3 small nucleolar RNA-associated protein MPP10

4

6

Small-scale

0.686

High

1046251

UTP15
U3 small nucleolar RNA-associated protein 15

4

20

Small-scale

0.686

High

825561

UTP25
U3 small nucleolar RNA-associated protein 25

3

2

Small-scale

0.663

High

1050163

RRP5
rRNA biogenesis protein RRP5

3

9

Small-scale

0.656

High

923254

ESF2
Pre-rRNA-processing protein ESF2

3

4

Small-scale

0.650

High

738260

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

3

6

Small-scale

0.643

High

763628

UTP20
U3 small nucleolar RNA-associated protein 20

3

2

Small-scale

0.640

High

919172

UTP8
U3 small nucleolar RNA-associated protein 8

3

2

Small-scale

0.640

High

924633

NAT10
RNA cytidine acetyltransferase

3

3

Small-scale

0.640

High

1046791

UTP14
U3 small nucleolar RNA-associated protein 14

3

8

Small-scale

0.640

High

1053531

BMS1
Ribosome biogenesis protein BMS1

3

7

Small-scale

0.640

High

1053535

RRP6
Exosome complex exonuclease RRP6

3

7

High-throughput

0.640

High

826213

FAF1
Protein FAF1

2

2

Small-scale

0.611

High

1053512

MRD1
Multiple RNA-binding domain-containing protein 1

2

6

Small-scale

0.611

High

546324

SSB1
Ribosome-associated molecular chaperone SSB1

2

12

High-throughput

0.601

High

584392

GCN2
eIF-2-alpha kinase GCN2

2

1

High-throughput

0.588

High

585378

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

9

Small-scale

0.584

High

632742

DBP4
ATP-dependent RNA helicase HCA4

2

16

Small-scale

0.584

High

673230

RRP7
Ribosomal RNA-processing protein 7

2

2

High-throughput

0.584

High

747049

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

2

7

Small-scale

0.584

High

754334

DCA13
Protein SOF1

2

19

Small-scale

0.584

High

758409

UTP11
U3 small nucleolar RNA-associated protein 11

2

2

Small-scale

0.584

High

806574

UTP9
U3 small nucleolar RNA-associated protein 9

2

2

Small-scale

0.584

High

816555

SNU13
13 kDa ribonucleoprotein-associated protein

2

6

Small-scale

0.584

High

818342

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

2

Small-scale

0.584

High

852604

ROK1
ATP-dependent RNA helicase ROK1

2

8

Small-scale

0.584

High

864521

MTR4
ATP-dependent RNA helicase DOB1

2

16

Small-scale

0.584

High

871057

NOL10
Ribosome biogenesis protein ENP2

2

3

Small-scale

0.584

High

923986

CSL4
Exosome complex component CSL4

2

4

High-throughput

0.584

High

925197

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

2

4

High-throughput

0.584

High

1053515

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

2

Small-scale

0.584

High

1053516

ESF1
Pre-rRNA-processing protein ESF1

2

2

Small-scale

0.584

High

1053517

RRP9
Ribosomal RNA-processing protein 9

2

18

Small-scale

0.584

High

1053519

BFR2
Protein BFR2

2

4

Small-scale

0.584

High

1053524

CMS1
Protein CMS1

2

2

Small-scale

0.584

High

1053525

RCL1
rRNA processing protein RCL1

2

3

Small-scale

0.584

High

1053529

UTP16
U3 small nucleolar RNA-associated protein 16

2

2

Small-scale

0.584

High

1053533

FCF2
rRNA-processing protein FCF2

2

2

Small-scale

0.584

High

1053536

MAK21
Ribosome biogenesis protein MAK21

2

7

High-throughput

0.584

High

1053540

NOP56
Nucleolar protein 56

2

12

Small-scale

0.584

High

1053544

EFG1P
rRNA-processing protein EFG1

2

2

Small-scale

0.584

High

1053547

NOP14
Nucleolar complex protein 14

2

3

Small-scale

0.584

High

779160

DHR2
Probable ATP-dependent RNA helicase DHR2

1

6

High-throughput

0.541

High

851019

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.541

High

722267

XPO1
Exportin-1

1

11

High-throughput

0.536

High

796851

SIF2
SIR4-interacting protein SIF2

1

18

High-throughput

0.536

High

503248

RS22A
Small ribosomal subunit protein uS8A

2

5

High-throughput

0.533

High

149960

RS9A
Small ribosomal subunit protein uS4A

1

7

High-throughput

0.479

High

435368

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

436520

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

512659

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

647228

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

672949

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

692625

NSR1
Nuclear localization sequence-binding protein

1

3

Small-scale

0.479

High

708219

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

709988

BMH1
Protein BMH1

1

3

High-throughput

0.479

High

735164

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

748049

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

751488

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

Small-scale

0.479

High

753591

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

782105

RL1D1
Ribosome biogenesis protein UTP30

1

8

High-throughput

0.479

High

792252

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

802906

DBP8
ATP-dependent RNA helicase DBP8

1

12

High-throughput

0.479

High

804751

RRP4
Exosome complex component RRP4

1

8

High-throughput

0.479

High

804960

LRP1
Exosome complex protein LRP1

1

2

High-throughput

0.479

High

808310

RRP8
25S rRNA

1

6

High-throughput

0.479

High

825084

RRT14
Regulator of rDNA transcription protein 14

1

2

High-throughput

0.479

High

826083

ULP2
Ubiquitin-like-specific protease 2

1

6

High-throughput

0.479

High

826843

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

843274

KRI1
Protein KRI1

1

1

Small-scale

0.479

High

863138

RRP41
Exosome complex component SKI6

1

19

High-throughput

0.479

High

864962

NOP9
Nucleolar protein 9

1

2

Small-scale

0.479

High

865420

URB2
Nucleolar pre-ribosomal-associated protein 2

1

2

High-throughput

0.479

High

871126

MTR3
Exosome complex component MTR3

1

2

High-throughput

0.479

High

874533

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

917481

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.479

High

918895

RRP46
Exosome complex component RRP46

1

18

High-throughput

0.479

High

918999

PESC
Pescadillo homolog

1

3

High-throughput

0.479

High

919759

PXR1
Protein PXR1

1

1

Small-scale

0.479

High

1039852

UTP17
NET1-associated nuclear protein 1

1

19

High-throughput

0.479

High

1042235

TOM1
E3 ubiquitin-protein ligase TOM1

1

11

High-throughput

0.479

High

1043282

HAS1
ATP-dependent RNA helicase HAS1

1

20

High-throughput

0.479

High

1046473

BUD22
Bud site selection protein 22

1

2

High-throughput

0.479

High

1051160

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1051710

RRP45
Exosome complex component RRP45

1

14

High-throughput

0.479

High

1053511

UTP21
U3 small nucleolar RNA-associated protein 21

1

17

High-throughput

0.479

High

1053513

SGD1
Suppressor of glycerol defect protein 1

1

3

High-throughput

0.479

High

1053514

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

1053523

NOP6
Nucleolar protein 6

1

1

Small-scale

0.479

High

1053526

RRP44
Exosome complex exonuclease DIS3

1

6

High-throughput

0.479

High

1053527

RRP40
Exosome complex component RRP40

1

3

High-throughput

0.479

High

1053528

SGO1
Shugoshin

1

2

High-throughput

0.479

High

1053532

NEW1
[NU+] prion formation protein 1

1

4

Small-scale

0.479

High

1053538

RRP42
Exosome complex component RRP42

1

14

High-throughput

0.479

High

1053539

DBP10
ATP-dependent RNA helicase DBP10

1

12

High-throughput

0.479

High

1053541

RRP36
rRNA biogenesis protein RRP36

1

3

High-throughput

0.479

High

1053543

RRP12
Ribosomal RNA-processing protein 12

1

4

High-throughput

0.479

High

1053548

PNO1
Pre-rRNA-processing protein PNO1

1

2

High-throughput

0.479

High

700294

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

Small-scale

0.458

High

1053546

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

Small-scale

0.458

High

525188

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

676361

MAS5
Mitochondrial protein import protein MAS5

1

11

High-throughput

0.445

High

727315

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

739466

ZUO1
Zuotin

1

9

High-throughput

0.445

High

742422

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

819832

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

433854

RL26A
Large ribosomal subunit protein uL24A

1

5

High-throughput

0.437

High

455268

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

514840

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

580087

HSC82
ATP-dependent molecular chaperone HSC82

1

7

Small-scale

0.437

High

812670

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

1033570

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

1043921

BUL2
Ubiquitin ligase-binding protein BUL2

1

2

Small-scale

0.437

High

1046306

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.437

High

1053522

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

1053530

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

1053545

RS22B
Small ribosomal subunit protein uS8B

1

5

High-throughput

0.437

High

453795

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.407

High

592508

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.407

High

752748

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

810765

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.407

High

823655

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.407

High

836899

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

1053520

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.407

High

1042986

THADA
tRNA

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025