HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40, WD40~zf-RING_16
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 974
+	Hs
		965034 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		WDR59_HUMAN (1-974): 0: 805: 100.00
+	Hs
		964963 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		WDR5_HUMAN (180-471): 1.59e-45: 169: 14.62
+	Mm
		965396 RBBP5_MOUSE (1-538): 2.61e-133: 399: 99.07		WDR5_MOUSE (180-471): 1.59e-45: 169: 14.62
+	Hs
		1145487 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		WDR5B_HUMAN (2-175): 4.36e-41: 156: 13.19
+	Dr
		1281780 Q7ZUU9_DANRE (1-506): 2.09e-113: 347: 89.02		Q7ZTX2_DANRE (180-471): 2.27e-45: 168: 14.95
+	Hs
		1145504 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		FBXW7_HUMAN (219-506): 2.83e-22: 104: 12.93
+	Hs
		1145510 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		WDR24_HUMAN (3-165): 4.81e-20: 98: 12.79
+	Hs
		1158951 FBXW7_HUMAN (52-391): 4.03e-62: 218: 13.08		RBBP7_HUMAN (43-334): 3.55e-61: 216: 20.46
+	Hs
		965141 FBXW7_HUMAN (52-391): 4.03e-62: 218: 13.08		WDR5_HUMAN (180-471): 1.59e-45: 169: 14.62
+	Hs
		845264 LIS1_HUMAN (104-423): 5.81e-52: 184: 9.65		WDR5_HUMAN (180-471): 1.59e-45: 169: 14.62
+	Sc
		673545 NLE1_YEAST (2-225): 8.15e-49: 178: 11.28		NLE1_YEAST (144-503): 1.33e-45: 174: 13.41
+	Hs
		964797 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		WDR5_HUMAN (180-471): 1.59e-45: 169: 14.62
+	Hs
		1380064 FBXW7_HUMAN (52-391): 4.03e-62: 218: 13.08		FBXW7_HUMAN (219-506): 2.83e-22: 104: 12.93
+	Ca
		515422 TUP1_CANAL (99-402): 5.09e-52: 186: 16.36		TUP1_CANAL (184-431): 3.67e-23: 106: 10.53
+	Hs
		845250 LIS1_HUMAN (104-423): 5.81e-52: 184: 9.65		LIS1_HUMAN (278-536): 1.85e-16: 84.9: 8.49
+	Mm
		988931 LIS1_MOUSE (104-423): 4.09e-52: 184: 9.65		LIS1_MOUSE (278-536): 1.67e-16: 84.9: 8.49
+	Hs
		1334151 POC1B_HUMAN (2-186): 8e-50: 180: 17.20		POC1A_HUMAN (268-629): 1.08e-17: 88.7: 9.79
+	Hs
		209230 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		PRP4_HUMAN (10-133): 6.61e-19: 93.3: 14.52
+	Hs
		964891 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39