HitPredict

Interactor 1: PK1 (Q17850)
Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1)
Gene: pak-1

Interactor 2: Q95PW9 (Q95PW9)
NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
Gene: nck-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.595

Property	Details
Experiments	31462781, 23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Ce			1 395
+	Hs
		221991 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		NCK2_HUMAN (2-393): 1.76e-85: 266: 37.82
+	Hs
		222072 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		NCK2_HUMAN (2-393): 1.76e-85: 266: 37.82
+	Hs
		222073 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		NCK2_HUMAN (2-393): 1.76e-85: 266: 37.82
+	Hs
		297090 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		NCK1_HUMAN (2-394): 4.11e-81: 255: 38.54
+	Hs
		593982 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		NCK1_HUMAN (2-394): 4.11e-81: 255: 38.54
+	Mm
		312746 PAK1_MOUSE (5-568): 8.84e-165: 481: 52.89		NCK1_MOUSE (2-394): 2.88e-81: 255: 38.29
+	Hs
		593983 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		NCK1_HUMAN (2-394): 4.11e-81: 255: 38.54
+	Hs
		440056 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		LCK_HUMAN (176-378): 5.22e-55: 190: 30.05
+	Hs
		463077 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		YES_HUMAN (213-375): 1e-53: 188: 34.68
+	Hs
		297104 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		ITSN1_HUMAN (5-269): 4.52e-32: 130: 14.77
+	Hs
		987602 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		GRB2_HUMAN (5-175): 2.31e-28: 112: 20.37
+	Hs
		987604 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		GRB2_HUMAN (5-175): 2.31e-28: 112: 20.37
+	Hs
		473411 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		HCK_HUMAN (2-186): 3.98e-18: 87.9: 16.13
+	Hs
		440530 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		FYN_HUMAN (6-108): 2.98e-17: 85.2: 19.05
+	Hs
		557274 PAK2_HUMAN (1-568): 4.03e-165: 481: 51.13		SRC_HUMAN (6-108): 1.01e-11: 68.5: 20.00
+	Mm
		632514 KPCA_MOUSE (100-566): 1.72e-132: 403: 18.83		GRB2_MOUSE (5-175): 1.69e-28: 112: 20.83
+	Mm
		686931 AKT1_MOUSE (223-572): 8.85e-130: 390: 21.05		P85A_MOUSE (272-393): 2.68e-20: 94.8: 20.00
+	Hs
		440402 AKT1_HUMAN (223-572): 3.2e-129: 388: 21.05		FYN_HUMAN (6-108): 2.98e-17: 85.2: 19.05
+	Mm
		431326 AKT1_MOUSE (223-572): 8.85e-130: 390: 21.05		SRC_MOUSE (6-108): 7.94e-16: 80.9: 20.00
+	Hs
		557128 AKT1_HUMAN (223-572): 3.2e-129: 388: 21.05		SRC_HUMAN (6-108): 1.01e-11: 68.5: 20.00