HitPredict

Interactor 1: Q3ZB59 (Q3ZB59)
Growth factor receptor bound protein 2-associated protein 2
Gene: Gab2

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.80	0.721

Property	Details
Experiments	10995764, 20697350
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Mm			1 217
+	Mm
		1221267 GAB2_MOUSE (1-665): 1.63e-175: 517: 99.85		GRB2_MOUSE (1-217): 1.59e-72: 220: 100.00
+	Hs
		988039 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Mm
		73036 GAB2_MOUSE (1-665): 1.63e-175: 517: 99.85		B1AT92_MOUSE (1-217): 3.11e-66: 204: 93.55
+	Hs
		1111771 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		GRAP_HUMAN (1-213): 1.13e-63: 198: 56.74
+	Hs
		594144 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		987613 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Mm
		313439 GAB2_MOUSE (1-665): 1.63e-175: 517: 99.85		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Mm
		683116 GAB2_MOUSE (1-665): 1.63e-175: 517: 99.85		LYN_MOUSE (135-215): 3.19e-10: 60.7: 24.10
+	Hs
		557534 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Hs
		463850 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10
+	Hs
		292883 GAB2_HUMAN (4-665): 8.8e-173: 510: 90.82		GRAP2_HUMAN (3-55): 7.11e-11: 62.5: 39.62
+	Hs
		440063 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		LCK_HUMAN (3-202): 4.02e-36: 134: 27.49
+	Hs
		593987 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		584536 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		VAV_HUMAN (3-60): 1.48e-15: 76.5: 43.10
+	Hs
		463085 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		YES_HUMAN (161-215): 4.3e-12: 66.5: 28.07
+	Hs
		557285 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Hs
		473414 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		HCK_HUMAN (116-215): 5.18e-11: 63.1: 19.61
+	Hs
		913647 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		VAV2_HUMAN (3-56): 6.05e-11: 63.1: 38.18
+	Hs
		463507 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10
+	Hs
		292833 GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81		GRAP2_HUMAN (3-55): 7.11e-11: 62.5: 39.62