HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: R4GMX3 (R4GMX3)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4)
Gene: COMMD3-BMI1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005829 - cytosol GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 469
+	Mm
		193404 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		BMI1_MOUSE (144-469): 3.13e-146: 422: 96.93
+	Hs
		717742 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		BMI1_HUMAN (144-469): 2.11e-149: 430: 100.00
+	Mm
		639478 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		BMI1_MOUSE (144-469): 3.13e-146: 422: 96.93
+	Mm
		193403 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		PCGF2_MOUSE (144-463): 4.85e-112: 336: 61.06
+	Hs
		718393 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF2_HUMAN (144-463): 1.09e-115: 345: 61.36
+	Mm
		620793 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF2_MOUSE (144-463): 4.85e-112: 336: 61.06
+	Hs
		987977 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF3_HUMAN (147-371): 3.08e-67: 217: 34.73
+	Mm
		193415 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RING2_MOUSE (113-375): 1.71e-59: 200: 15.39
+	Hs
		988015 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF1_HUMAN (119-372): 4.08e-62: 204: 33.71
+	Hs
		988012 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		RING2_HUMAN (113-375): 2.16e-59: 200: 15.39
+	Hs
		988016 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF6_HUMAN (141-378): 2.91e-59: 200: 34.55
+	Hs
		987986 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF5_HUMAN (144-371): 5.82e-54: 183: 30.44
+	Mm
		1207257 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF3_MOUSE (147-371): 2.11e-65: 212: 34.73
+	Mm
		1246747 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF1_MOUSE (119-372): 3.79e-62: 204: 33.08
+	Mm
		1321732 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		RING2_MOUSE (113-375): 1.71e-59: 200: 15.39
+	Mm
		1307909 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF6_MOUSE (141-378): 3.34e-57: 194: 35.37
+	Mm
		1112809 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF5_MOUSE (144-371): 2.58e-57: 192: 30.83
+	Mm
		193402 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RING1_MOUSE (123-258): 3.02e-36: 140: 21.17
+	Hs
		987956 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		RING1_HUMAN (123-258): 6.48e-36: 139: 21.17