HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GAB2 (Q9Z1S8)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97)
Gene: GAB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 665
+	Mm
		1191823 GRB2_MOUSE (1-217): 1.59e-72: 220: 100.00		Q3ZB59_MOUSE (1-665): 4.46e-175: 515: 99.85
+	Hs
		988039 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		GAB2_HUMAN (4-665): 8.8e-173: 510: 90.67
+	Mm
		73036 B1AT92_MOUSE (1-217): 3.11e-66: 204: 93.55		GAB2_MOUSE (1-665): 1.63e-175: 517: 100.00
+	Hs
		1111771 GRAP_HUMAN (1-213): 1.13e-63: 198: 56.74		GAB2_HUMAN (4-665): 8.8e-173: 510: 90.67
+	Hs
		987613 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81
+	Mm
		1221262 GRB2_MOUSE (1-217): 1.59e-72: 220: 100.00		GAB1_MOUSE (5-664): 4.06e-120: 375: 36.23
+	Hs
		987801 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		GAB3_HUMAN (5-656): 4.26e-91: 296: 31.22
+	Hs
		440063 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81
+	Hs
		1106474 PTK6_HUMAN (4-141): 7.17e-23: 97.1: 38.93		GAB1_HUMAN (5-664): 1.33e-121: 379: 35.81
+	Hs
		215914 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		SYNJ1_HUMAN (123-640): 1.36e-51: 195: 14.80
+	Hs
		987707 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PKHA7_HUMAN (1-608): 3.67e-49: 187: 13.06
+	Hs
		987954 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PKHA2_HUMAN (3-227): 4.14e-44: 165: 21.83
+	Hs
		987694 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PKHS1_HUMAN (8-314): 4.25e-43: 163: 17.70
+	Dm
		1061478 GRAP_DROME (1-215): 5.56e-60: 189: 61.86		DOS_DROME (7-464): 2.16e-41: 163: 20.16
+	Hs
		215893 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		SYNJ1_HUMAN (123-640): 1.36e-51: 195: 14.80
+	Hs
		440118 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		PKHA7_HUMAN (1-608): 3.67e-49: 187: 13.06
+	Hs
		440215 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		PKHA5_HUMAN (1-421): 7.41e-49: 186: 16.24
+	Hs
		440251 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		PKHA6_HUMAN (1-536): 8.47e-42: 165: 14.39
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (123-640): 1.36e-51: 195: 14.80
+	Hs
		987772 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		SESQ1_HUMAN (8-117): 3.48e-13: 72: 27.43