HitPredict

Interactor 1: KCD21 (Q4G0X4)
BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Gene: KCTD21

Interactor 2: KCD11 (Q693B1)
BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11)
Gene: KCTD11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21472142
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTB_2~BTB_2
Common GO terms	GO:0016567 - protein ubiquitination GO:0045879 - negative regulation of smoothened signaling pathway GO:0051260 - protein homooligomerization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 260 Hs			1 232
+	Hs
		1194635 KCD21_HUMAN (1-260): 1.31e-87: 262: 100.00		KCD21_HUMAN (1-232): 5.13e-78: 237: 38.08
+	Hs
		1229412 KCD11_HUMAN (28-259): 2.02e-67: 210: 37.66		KCD11_HUMAN (1-232): 1.18e-85: 255: 100.00
+	Hs
		1194649 KCD21_HUMAN (1-260): 1.31e-87: 262: 100.00		KCD15_HUMAN (2-214): 1.1e-49: 165: 21.13
+	Hs
		1194639 KCD21_HUMAN (1-260): 1.31e-87: 262: 100.00		KCTD1_HUMAN (2-214): 6.35e-46: 154: 21.60
+	Hs
		1452134 KCND2_HUMAN (2-258): 3.19e-75: 241: 18.22		KCTD5_HUMAN (9-174): 1.83e-50: 166: 16.27
+	Hs
		1130029 KCND2_HUMAN (2-258): 3.19e-75: 241: 18.22		KCTD2_HUMAN (9-174): 4.57e-48: 160: 17.47
+	Hs
		1328683 KCND2_HUMAN (2-258): 3.19e-75: 241: 18.22		KCD17_HUMAN (13-165): 2.08e-43: 150: 19.61
+	Hs
		1229416 KCD11_HUMAN (28-259): 2.02e-67: 210: 37.66		KCD15_HUMAN (2-214): 1.1e-49: 165: 21.13
+	Hs
		1194643 KCD21_HUMAN (1-260): 1.31e-87: 262: 100.00		KCTD6_HUMAN (1-78): 2.93e-27: 106: 50.00
+	Mm
		1296475 KCND3_MOUSE (2-258): 3.53e-73: 237: 19.17		BACD1_MOUSE (1-142): 5.49e-36: 131: 25.81
+	Hs
		1229413 KCD11_HUMAN (28-259): 2.02e-67: 210: 37.66		KCTD1_HUMAN (2-214): 6.35e-46: 154: 21.60
+	Mm
		595025 KCNA1_MOUSE (3-258): 5.44e-61: 201: 16.61		BACD1_MOUSE (1-142): 5.49e-36: 131: 25.81
+	Hs
		1229415 KCD11_HUMAN (28-259): 2.02e-67: 210: 37.66		KCTD6_HUMAN (1-78): 2.93e-27: 106: 50.00
+	Hs
		643019 KCNA3_HUMAN (3-258): 5.98e-62: 206: 16.30		KCD12_HUMAN (1-121): 9.29e-28: 109: 24.79
+	Hs
		1432553 BACD3_HUMAN (2-195): 1.1e-51: 172: 30.73		BACD3_HUMAN (1-141): 1.12e-38: 138: 25.49
+	Mm
		1296217 BACD3_MOUSE (2-195): 3.36e-51: 171: 30.73		BACD1_MOUSE (1-142): 5.49e-36: 131: 25.81
+	Hs
		1361867 BACD3_HUMAN (2-195): 1.1e-51: 172: 30.73		BACD1_HUMAN (1-142): 1.29e-35: 130: 25.81
+	Hs
		1117923 BACD3_HUMAN (2-195): 1.1e-51: 172: 30.73		BACD2_HUMAN (1-141): 1.17e-34: 127: 24.68
+	Hs
		1067219 KCNA1_HUMAN (3-258): 5.21e-61: 201: 16.24		KCNRG_HUMAN (2-86): 2.98e-20: 88.3: 34.12
+	Hs
		648784 KCNA4_HUMAN (3-258): 2.19e-51: 179: 14.39		KCNRG_HUMAN (2-86): 2.98e-20: 88.3: 34.12