Protein: KCD21
BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)

Gene: KCD21, KCTD21
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q4G0X4

Gene Ontology (top 5):
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0042802 - identical protein binding
GO:0042826 - histone deacetylase binding
GO:0045879 - negative regulation of smoothened signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1194635

KCD21
BTB/POZ domain-containing protein KCTD21

3

19

Small-scale

0.843

High

1194649

KCD15
BTB/POZ domain-containing protein KCTD15

2

19

Small-scale

0.812

High

1113259

CUL3
Cullin-3

2

20

High-throughput

0.789

High

1194653

KLH14
Kelch-like protein 14

3

6

High-throughput

0.770

High

1194639

KCTD1
BTB/POZ domain-containing protein KCTD1

1

18

Small-scale

0.724

High

1194654

DJB11
DnaJ homolog subfamily B member 11

4

13

High-throughput

0.630

High

1194637

KCD11
BTB/POZ domain-containing protein KCTD11

1

20

Small-scale

0.618

High

1194643

KCTD6
BTB/POZ domain-containing protein KCTD6

1

19

Small-scale

0.618

High

1122788

DOC2A
Double C2-like domain-containing protein alpha

3

4

High-throughput

0.609

High

1194646

RNF25
E3 ubiquitin-protein ligase RNF25

2

1

High-throughput

0.606

High

1194647

ZMY19
Zinc finger MYND domain-containing protein 19

3

3

High-throughput

0.591

High

1194642

WDFY1
WD repeat and FYVE domain-containing protein 1

2

7

High-throughput

0.574

High

1194645

TRIB2
Tribbles homolog 2

2

6

High-throughput

0.574

High

1194650

DUS22
Dual specificity protein phosphatase 22

2

1

High-throughput

0.574

High

248713

PEPL
Periplakin

2

20

High-throughput

0.553

High

1165272

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

14

High-throughput

0.553

High

1194648

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

9

High-throughput

0.553

High

1194638

LIRA6
Leukocyte immunoglobulin-like receptor subfamily A member 6

2

10

High-throughput

0.533

High

1022083

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

8

High-throughput

0.489

High

1194636

ANR39
Ankyrin repeat domain-containing protein 39

1

19

High-throughput

0.489

High

872390

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

899658

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

11

Small-scale

0.437

High

963077

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

Small-scale

0.437

High

1099691

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

Small-scale

0.437

High

1099971

TIF1B
Transcription intermediary factor 1-beta

1

15

Small-scale

0.437

High

1194641

CEP97
Centrosomal protein of 97 kDa

1

20

Small-scale

0.437

High

1194655

MAGD1
Melanoma-associated antigen D1

1

3

Small-scale

0.437

High

91871

C9JWL8
Leukocyte immunoglobulin like receptor B3

1

10

High-throughput

0.407

High

268956

LIRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3

1

10

High-throughput

0.407

High

1194644

CV015
Uncharacterized protein C22orf15

3

0

High-throughput

0.346

High

1194651

MRGBP
MRG/MORF4L-binding protein

2

0

High-throughput

0.328

High

964542

UFM1
Ubiquitin-fold modifier 1

2

0

High-throughput

0.316

High

1194640

CRLF3
Cytokine receptor-like factor 3

2

0

High-throughput

0.316

High

1194652

NRK1
Nicotinamide riboside kinase 1

2

0

High-throughput

0.316

High

1187029

LSM12
Protein LSM12

1

0

High-throughput

0.279

Low

378998

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.249

Low

1192029

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025