HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: SIGIR (Q6IA17)
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Gene: SIGIRR

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	12925853, 15866876
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	TIR~TIR
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 839 Hs			1 410
+	Hs
		120186 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		TLR6_HUMAN (95-322): 4.25e-68: 231: 17.99
+	Hs
		120154 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		TLR1_HUMAN (95-312): 9.72e-68: 230: 18.78
+	Hs
		120116 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		TLR5_HUMAN (96-329): 1.09e-50: 184: 16.60
+	Hs
		120109 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		TLR4_HUMAN (140-316): 1.42e-46: 173: 24.86
+	Mm
		1351519 TLR4_MOUSE (1-823): 4.8e-132: 416: 67.23		TLR4_MOUSE (136-315): 3.48e-47: 174: 23.91
+	Mm
		1163939 TLR13_MOUSE (37-824): 2.5e-96: 324: 21.08		TLR13_MOUSE (82-316): 3.24e-62: 218: 18.85
+	Hs
		237522 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		TLR6_HUMAN (95-322): 4.25e-68: 231: 17.99
+	Hs
		237496 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		TLR1_HUMAN (95-312): 9.72e-68: 230: 18.78
+	Hs
		237517 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		TLR10_HUMAN (95-324): 1.49e-66: 228: 18.60
+	Hs
		1073332 TLR10_HUMAN (28-817): 6.13e-88: 298: 19.63		TLR1_HUMAN (95-312): 9.72e-68: 230: 18.78
+	Hs
		237446 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		TLR2_HUMAN (94-307): 3.42e-63: 218: 19.47
+	Hs
		120173 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92
+	Mm
		607581 TLR4_MOUSE (1-823): 4.8e-132: 416: 67.23		MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45
+	Hs
		237420 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		TLR5_HUMAN (96-329): 1.09e-50: 184: 16.60
+	Mm
		607582 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45
+	Hs
		237513 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92
+	Hs
		237435 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92
+	Hs
		1306774 TLR10_HUMAN (28-817): 6.13e-88: 298: 19.63		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92